机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.神经内科首都医科大学宣武医院[2]Beijing Key Laboratory of Neuromodulation, Beijing, China.[3]School of Biomedical Engineering, Health Science Center, Shenzhen University, Shenzhen, China.[4]Department of Medical Information Engineering, Sichuan University, Chengdu, China.[5]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Objective: In presurgical evaluation of temporal lobe epilepsy (TLE), selection of the resection side is challenging when bilateral temporal epileptiform discharges or structural abnormalities are present. We aim to evaluate the lateralization value of beamformer analysis of magnetoencephalography (MEG) in TLE. Methods: MEG data from 14 TLE patients were analyzed through beamformer analysis. We measured the hemispherical power distribution of beamformer sources and calculated the lateralization index (LI). We calculated the LI at multiple frequencies to explore the frequency dependency and at the delta frequency to define laterality. LI values ranging from -1 to -0.05 indicated right hemispheric dominance. LI values ranging from 0.05 to 1 indicated left hemispheric dominance. LI values ranging from -0.05 to 0.05 defined bilaterality. We measured the power of beamformer sources with a 9-s duration to explore time dependency. Results: The beamformer analysis showed that 10/14 patients had power dominance ipsilateral to resection. The delta frequency band had a higher lateralization value than other frequency bands. A time-dependent power fluctuation was found in the delta frequency band. Conclusions: MEG beamformer analysis, especially in the delta band, might efficiently provide additional information regarding lateralization in TLE.
基金：
This work was supported by the National High Technology
Research and Development Program of China [No.
2015AA020514] and Beijing Municipal Science and Technology
Commission [No. Z161100002616001].
第一作者机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.[2]Beijing Key Laboratory of Neuromodulation, Beijing, China.
通讯作者：
通讯机构：[1]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China.[2]Beijing Key Laboratory of Neuromodulation, Beijing, China.[4]Department of Medical Information Engineering, Sichuan University, Chengdu, China.[5]Center of Epilepsy, Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
推荐引用方式(GB/T 7714)：
Lin Yicong,Zhang Zhiguo,Zhang Xiating,et al.Lateralization Value of Low Frequency Band Beamformer Magnetoencephalography Source Imaging in Temporal Lobe Epilepsy[J].FRONTIERS IN NEUROLOGY.2018,9(OCT):829.doi:10.3389/fneur.2018.00829.
APA：
Lin, Yicong,Zhang, Zhiguo,Zhang, Xiating,Yang, Yingxue,Huang, Zhaoyang...&Wang, Yuping.(2018).Lateralization Value of Low Frequency Band Beamformer Magnetoencephalography Source Imaging in Temporal Lobe Epilepsy.FRONTIERS IN NEUROLOGY,9,(OCT)
MLA：
Lin, Yicong,et al."Lateralization Value of Low Frequency Band Beamformer Magnetoencephalography Source Imaging in Temporal Lobe Epilepsy".FRONTIERS IN NEUROLOGY 9..OCT(2018):829
