机构：[1]Eye Hospital of China Academy of Chinese Medical Sciences, Beijing, China[2]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China[3]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China[4]Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing, China眼科首都医科大学宣武医院[5]Queensland Eye Institute, University of Queensland, Brisbane, Queensland, Australia[6]University of Queensland, Brisbane, Queensland, Australia[7]Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
PurposeTo compare the orbital cerebral spinal fluid pressure (CSFP) and trans-lamina cribrosa pressure difference (TLCPD) determined noninvasively in ocular hypertensive (OH) subjects and controls. MethodsCross-sectional observational study. Magnetic resonance imaging was used to measure orbital subarachnoid space width (OSASW). The CSFP (mmHg) was estimated from a published formula as 17.54xMRI derived OSASW at 15mm behind the globe+0.47xbody mass index+0.13xmean arterial blood pressure -21.52. Estimated TLCPD was calculated as IOP- CSFP. ResultsThe orbital subarachnoid space width was significantly wider (p=0.01) in the OH group than in the control group at all three measurement locations. The MRI derived CSFP value in OH (14.92.9mmHg) was significantly higher than in the normal group (12.0 +/- 2.8mmHg; p<0.01). The estimated TLCPD value in OH (9.0 +/- 4.2mmHg) was significantly higher than in controls (3.6 +/- 3.0mmHg; p<0.01). ConclusionThe wider OSASW and higher estimated CSFP in OH subjects suggest a higher orbital CSFP. Despite a higher orbital CSFP that could be protective, the higher TLCPD in OH may play a significant role in the risk of developing glaucoma.
基金：
National Natural Science Foundation of China(81271005 and 81400391),
Beijing Natural Science Foundation (7122038),
Award of Excellent Doctoral Dissertation in Beijing (Beijing YXBS Grant PXM2010_014226_07_000061 and PXM2011_014226_07_000114),
Donation by China Health and Medical Development Foundation,
Beijing Municipal Administration of Hospital’s Youth Programme (QML20160203).
第一作者机构：[1]Eye Hospital of China Academy of Chinese Medical Sciences, Beijing, China
通讯作者：
通讯机构：[*1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, 1 Dongjiaominxiang Street, Dongcheng District, Beijing 100730, China[*2]Beijing Institute of Ophthalmology, Capital Medical University, Beijing Tongren Hospital, 17 Hougou Lane, Chongwenmen, Beijing, 100005, China[*3]Eye Hospital of China Academy of Chinese Medical Sciences 33 Lugu Road, Shijingshan District Beijing, 100040 China
推荐引用方式(GB/T 7714)：
Xiaobin Xie ,Weiwei Chen ,Zhen Li ,et al.Noninvasive evaluation of cerebrospinal fluid pressure in ocular hypertension: a preliminary study[J].ACTA OPHTHALMOLOGICA.2018,96(5):e570-e576.doi:10.1111/aos.13724.
APA：
Xiaobin Xie,,Weiwei Chen,,Zhen Li,,Ravi Thomas,,Yong Li,...&Ningli Wang.(2018).Noninvasive evaluation of cerebrospinal fluid pressure in ocular hypertension: a preliminary study.ACTA OPHTHALMOLOGICA,96,(5)
MLA：
Xiaobin Xie,,et al."Noninvasive evaluation of cerebrospinal fluid pressure in ocular hypertension: a preliminary study".ACTA OPHTHALMOLOGICA 96..5(2018):e570-e576
