机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China[2]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China[3]Department of Neurosurgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China[4]Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University Heidelberg, Mannheim, Germany[5]Department of Ophthalmology, Xuanwu Hospital, Capital Medical University, Beijing, China眼科首都医科大学宣武医院[6]Department of Ophthalmology, Eye Hospital of China Academy of Chinese Medical Sciences, Beijing, China[7]Hamilton Glaucoma Center and Department of Ophthalmology, University of California-San Diego, La Jolla, California, United States
PURPOSE. To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) on retinal nerve fiber layer (RNFL) thickness and neuroretinal rim area of the optic nerve head. METHODS. This experimental study included nine monkeys that underwent implantation of a lumbar-peritoneal cerebrospinal fluid (CSF) shunt. In the study group (n = 4 monkeys), the shunt was opened to achieve a CSF of approximately 40 mm H2O, while the shunt remained closed in the control group (n = 5 monkeys). At baseline and in monthly intervals thereafter, optical coherence tomographic and photographic images of the optic nerve head and RNFL were taken of all monkeys. RESULTS. Two out of four monkeys in the study group showed bilaterally a progressive reduction in RNFL thickness between 12% and 30%, reduction in neuroretinal rim area and volume, and increase in cup-to-disc area ratios. A third monkey developed a splinter-like disc hemorrhage in one eye. The fourth monkey in the study group did not develop morphologic changes during follow-up, nor did any monkey in the control group. CONCLUSIONS. Experimental and chronic reduction in CSF in monkeys was associated with the development of an optic neuropathy in some monkeys.
基金：
National Natural Science Foundation of China(81271005, 81300767),
Beijing Natural Science Foundation(7122038),
China Health and Medical Development Foundation.
第一作者机构：[1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China[2]Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[*1]Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, No. 1 Dongjiaominxiang Street, Dongcheng District, Beijing, China, 100730
推荐引用方式(GB/T 7714)：
Diya Yang ,Jidi Fu ,Ruowu Hou ,et al.Optic Neuropathy Induced by Experimentally Reduced Cerebrospinal Fluid Pressure in Monkeys[J].INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE.2014,55(5):3067-73.doi:10.1167/iovs.13-13657.
APA：
Diya Yang,,Jidi Fu,,Ruowu Hou,,Kegao Liu,,Jost B. Jonas,...&Ningli Wang.(2014).Optic Neuropathy Induced by Experimentally Reduced Cerebrospinal Fluid Pressure in Monkeys.INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE,55,(5)
MLA：
Diya Yang,,et al."Optic Neuropathy Induced by Experimentally Reduced Cerebrospinal Fluid Pressure in Monkeys".INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55..5(2014):3067-73
医学