机构：[1]Central Laboratory, Department of General Surgery, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Xuan Wu Hospital, Capital Medical University, Beijing, China普通外科首都医科大学宣武医院[2]Department of Liver Cancer Center, Beijing 302 Hospital, Beijing, China[3]Nursing Department, Beijing 302 Hospital, Beijing, China[4]Central Laboratory, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Xuan Wu Hospital, Capital Medical University, Beijing, China.首都医科大学宣武医院
U Alzheimer's disease (AD) is one of the most common and devastating aging related neurodegenerative diseases. Aging is a natural physiological process, a progressive deterioration of the overall homeostatic brain mechanisms, accompanied by cognitive decline. CXCL12/CXCR4 chemokine signaling plays a critical role in modulating various nervous system developmental processes and in regulating synaptic plasticity. In this article, we have firstly shown that CXCR4 is critical for cell proliferation and cytotoxicity in the SH-SY5Y cell model. Moreover, it has been firstly demonstrated that CXCR4 colocalized with AKT on the membrane and regulated the AKT activation to prevent aging and AD. In a word, we supply a novel pathway that CXCR4 pathway stimulated by CXCL12 regulated AKT activation, CREB phosphorylation and P53 level to affect the process of aging and AD. Therefore, CXCR4 may be a novel target and biomarker for the diagnosis and treatment of AD and aging.
基金：
National Natural Science Foundation of China [81502553]; China Postdoctoral Science Foundation [2017M610947, 2017T100091]; Beijing Postdoctoral Research Foundation [2017zz-115]
第一作者机构：[1]Central Laboratory, Department of General Surgery, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Xuan Wu Hospital, Capital Medical University, Beijing, China[2]Department of Liver Cancer Center, Beijing 302 Hospital, Beijing, China
通讯作者：
通讯机构：[1]Central Laboratory, Department of General Surgery, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Xuan Wu Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
H. LI,L. HAO,Y. LI,et al.Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging[J].JOURNAL OF NUTRITION HEALTH & AGING.2018,22(7):785-789.doi:10.1007/s12603-018-1013-9.
APA：
H. LI,L. HAO,Y. LI&R. WANG.(2018).Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging.JOURNAL OF NUTRITION HEALTH & AGING,22,(7)
MLA：
H. LI,et al."Reducing CXCR4 Resulted in Impairing Proliferation and Promoting Aging".JOURNAL OF NUTRITION HEALTH & AGING 22..7(2018):785-789
