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The Value of Contrast-Enhanced Ultrasonography Combined with Real-Time Strain Elastography in the Early Diagnosis of Prostate Cancer

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机构: [1]Departments of Ultrasonography, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China [2]Departments of Ultrasonography, Inner Mongolia Autonomous Region People's Hospital, Hohhot 010017, China [3]Departments of Urology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China [4]Departments of Pathology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China
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关键词: elastography contrast agent prostatic neoplasms biopsy ultrasonography

摘要:
To evaluate the performance of a combination of real-time strain elastography (RTSE) and contrast-enhanced transrectal ultrasound (CETRUS) for prostate cancer detection. Patients with serum prostate-specific antigen (PSA) levels of >= 4.0 ng/ml were prospectively enrolled between June 2014 and December 2016. 153 prostate nodules diagnosed by conventional ultrasound were prospectively enrolled and examined by CETRUS and RTSE before a biopsy. Multivariate logistic regression models were established for CETRUS, and CETRUS combined with RTSE to diagnose prostate malignancy. The diagnostic performances of CETRUS, RTSE, and their combined use were evaluated with the receiver operating characteristic (ROC) curve. The multivariate logistic regression for CETRUS combined with RTSE showed that enhanced strength, enhanced uniformity, and elasticity scores were the independent predictors of prostate malignancy. The area under the ROC curve of CETRUS combined with RTSE (0.921 +/- 0.023) was higher than that of CETRUS and RTSE (0.88 +/- 0.029 and 0.80 +/- 0.038, respectively; both p<0.05). Moreover, the sensitivity, accuracy and negative predictive value of CETRUS combined with RTSE were 92.1%, 86.2%, and 84.6%, respectively. The omission diagnostic rate of CETRUS combined with RTSE (7.9%) was reduced. And the diagnostic accuracy of CETRUS combined with RTSE was significantly higher than that of CETRUS and RTSE (p<0.05). While the diagnostic accuracy of CETRUS was close to the RTSE, the difference was not statistically significant (p>0.05). The combined RTSE with CETRUS approach significantly improved the sensitivity and overall accuracy for correctly identifying prostate cancer.

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出版当年[2017]版
大类 | 2 区 医学
小类 | 2 区 老年医学
最新[2023]版:
大类 | 2 区 医学
小类 | 3 区 老年医学
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出版当年[2016]版:
Q1 GERIATRICS & GERONTOLOGY
最新[2023]版:
Q1 GERIATRICS & GERONTOLOGY

影响因子: 最新[2023版] 最新五年平均 出版当年[2016版] 出版当年五年平均 出版前一年[2015版] 出版后一年[2017版]

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第一作者机构: [1]Departments of Ultrasonography, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China
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通讯机构: [*1]Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
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