机构：[a]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[b]Beijing Key Laboratory of Neuromodulation, Beijing, China[c]The Clinical Hospital of Chengdu Brain Science Institute, MOE Key Lab for Neuroinformation, University of Electronic Science and Technology of China, Chengdu, China[d]Department of Radiology, Xuan Wu Hospital, Capital Medical University, Beijing, China放射科首都医科大学宣武医院[e]Central Laboratory, Xuan Wu Hospital, Capital Medical University, Beijing Institute for Brain Disorders, Center of Alzheimer's Disease, Beijing, China首都医科大学宣武医院[f]Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Disease of Ministry of Education, Beijing, China
Objective: The hubs of the brain network play a key role in integrating and transferring information between different functional modules. However, whether the changed pattern in functional network hubs contributes to the onset of leg discomfort symptoms in restless legs syndrome (RLS) patients remains unclear. Using resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory methods, we investigated whether alterations of hubs can be detected in RLS.& para;& para;Methods: First, we constructed the whole-brain voxelwise functional connectivity and calculated a functional connectivity strength (FCS) map in each of 16 drug-naive idiopathic RLS patients and 26 gender- and age-matched healthy control (HC) subjects. Next, a two-sample t test was applied to compare the FCS maps between HC and RLS patients, and to identify significant changes in FCS in RLS patients. To further elucidate the corresponding changes in the functional connectivity patterns of the aberrant hubs in RLS patients, whole-brain resting-state functional connectivity analyses for the hub areas were performed.& para;& para;Results: The hub analysis revealed decreased FCS in the cuneus, fusiform gyms, paracentral lobe, and precuneus, and increased FCS in the superior frontal gyms and thalamus in idiopathic drug-naive RLS patients. Subsequent functional connectivity analyses revealed decreased functional connectivity in sensorimotor and visual processing networks and increased functional connectivity in the affective cognitive network and cerebellar-thalamic circuit. Furthermore, the mean FCS value in the superior frontal gyms was significantly correlated with Hamilton Anxiety Rating Scale scores in RLS patients, and the mean FCS value in the fusiform gyms was significantly correlated with Hamilton Depression Rating Scale scores.& para;& para;Conclusions: These findings may provide novel insight into the pathophysiology of RLS. (C) 2018 Elsevier B.V. All rights reserved.
基金：
the National Natural Science Foundation of China, Grant Numbers 81271494, 81301138,81030028, 31500867, and 81225012.
第一作者机构：[a]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China[b]Beijing Key Laboratory of Neuromodulation, Beijing, China
共同第一作者：
通讯作者：
通讯机构：[*1]Central Laboratory, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China.[*2]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Chunyan Liu,Jiaojian Wang,Yue Hou,et al.Mapping the changed hubs and corresponding functional connectivity in idiopathic restless legs syndrome[J].SLEEP MEDICINE.2018,45:132-139.doi:10.1016/j.sleep.2017.12.016.
APA：
Chunyan Liu,Jiaojian Wang,Yue Hou,Zhigang Qi,Li Wang...&Yuping Wang.(2018).Mapping the changed hubs and corresponding functional connectivity in idiopathic restless legs syndrome.SLEEP MEDICINE,45,
MLA：
Chunyan Liu,et al."Mapping the changed hubs and corresponding functional connectivity in idiopathic restless legs syndrome".SLEEP MEDICINE 45.(2018):132-139
