机构：[1]Xuanwu Hospital, Capital Medical University, Beijing, China,首都医科大学宣武医院[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Capital Medical University, Beijing, China,[3]Beijing Tongren Hospital, Beijing, China
Purpose: To investigate spontaneous brain activity amplitude alterations in single and relapsing optic neuritis (sON and rON, respectively) and their relationships with clinical variables. Methods: In total, 42 patients with sON, 35 patients with rON and 50 healthy volunteers were recruited. Resting-state functional Magnetic Resonance Imaging (rs-fMRI) scans were acquired for all participants and compared to investigate the changes in the amplitude of low-frequency fluctuations (ALFFs) among the three groups. The relationships between the ALFFs in regions with significant differences in the groups and clinical variables, including the logarithm of minimal angle of resolution (LogMAR), Expanded Disability Status Scale (EDSS) score and disease duration, were further explored. Results: Compared with healthy volunteers, the sON and rON patients showed significantly decreased ALFFs in several regions of the occipital and temporal lobes (i.e., inferior occipital gyrus and superior temporal gyrus; corrected p < 0.01 using AlphaSim). The sON patients showed significantly increased ALFFs in the left caudate and certain regions in the frontal lobes (i.e., medial frontal gyrus), whereas the rON patients showed increased ALFFs in the bilateral inferior temporal gyrus and left medial frontal gyrus (corrected p < 0.01 using AlphaSim). Significantly decreased ALFFs were observed in the right inferior parietal lobule (IPL), left posterior cingulate and precuneus in the rON patients compared with those in the sON patients (corrected p < 0.01 using AlphaSim). Significant correlations were observed between the disease duration and ALFF in the left middle temporal gyrus, left inferior occipital gyrus, right lingual gyrus and right IPL (p < 0.05). Conclusion: Functional impairment and adaptation occurred in both the sON and rON patients. Impairment mainly involved the occipital cortex, and functional adaptions predominantly occurred in the frontal lobe. Functional damage was more severe in the rON patients than in the sON patients and correlated with the disease duration.
基金：
the ECTRIMS-MAGNMIS Fellowship from ECTRIMS (YL),
the National Science Foundation of China (Grant Nos. 81101038, 81401377, 81471221 and 81230028),
the National Basic Research Program of China (2013CB966900),
the Beijing Natural Science fund(Grant No. 7133244),
the Beijing Nova Programme (xx2013045),
Beijing Municipal Administration of Hospital Clinical Medicine Development of Special Funding Support (code: ZYLX201609),
Key Projects in the National Science & Technology Pillar Program during the Twelfth Five-year Plan Period (2012BAI10B04).
第一作者机构：[1]Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Capital Medical University, Beijing, China,
通讯作者：
通讯机构：[1]Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Capital Medical University, Beijing, China,
推荐引用方式(GB/T 7714)：
Zhuoqiong Ren,Yaou Liu,Kuncheng Li,et al.Baseline Brain Activity Changes in Patients With Single and Relapsing Optic Neuritis[J].FRONTIERS IN HUMAN NEUROSCIENCE.2018,12:doi:10.3389/fnhum.2018.00144.
APA：
Zhuoqiong Ren,Yaou Liu,Kuncheng Li,Yunyun Duan,Huang Jing...&Bei Mao.(2018).Baseline Brain Activity Changes in Patients With Single and Relapsing Optic Neuritis.FRONTIERS IN HUMAN NEUROSCIENCE,12,
MLA：
Zhuoqiong Ren,et al."Baseline Brain Activity Changes in Patients With Single and Relapsing Optic Neuritis".FRONTIERS IN HUMAN NEUROSCIENCE 12.(2018)
