机构：[1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China,放射科首都医科大学宣武医院[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Capital Medical University, Beijing, China,[3]Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China,[4]Brain and Mind Centre, Sydney Medical School Nepean, The University of Sydney, Sydney, NSW, Australia,[5]School of Instrumentation Science and Opto-electronics Engineering, Beihang University, Beijing, China,[6]Department of Neurology, Tongren Hospital, Capital Medical University, Beijing, China,[7]Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院
Previous studies have revealed brain adaptations to injury that occurs in optic neuritis (ON); however, the mechanisms underlying the functional connectivity (FC) and gray matter volume (GMV) changes in ON have not been clarified. Here, 51 single attack ON patients and 45 recurrent attacks ON patients were examined using structural MRI and resting-state functional MRI (RS-fMRI), and compared to 49 age- and gender-matched healthy controls (HC). FC analysis with a seed in primary visual cortex (V1 area) was used to assess the differences among three groups. Whole brain GMV was assessed using voxel-based morphometry (VBM). Correlation analyses were performed between FC results, structural MRI and clinical variables. We found positive correlations between the Paced Auditory Serial Addition Test (PASAT) score and FC in V1 area with bilateral middle frontal gyrus. Disease duration is significantly negatively related to FC in V1 area with the left inferior parietal lobule. Compared to the HC, single attack ON patients were found to have decreased FC values in the frontal, temporal lobes, right inferior occipital gyrus, right insula, right inferior parietal lobule, and significant increased FC values in the left thalamus. Recurrent attacks ON patients had the same pattern with single attack ON. No significant differences were found in brain GMV among three groups. This study provides the imaging evidence that impairment and compensation of V1 area connectivity coexist in ON patients, and provides important insights into the underlying neural mechanisms of ON.
基金：
Beijing Municipal Administration of Hospitals [ZYLX201609]; Beijing Municipal Commission of Science and Technology [Z171100000117001]; Beijing Municipal Administration of Hospitals' Youth Programme [008-0110]
第一作者机构：[1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Capital Medical University, Beijing, China,
通讯作者：
通讯机构：[1]Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics, Capital Medical University, Beijing, China,[7]Department of Nuclear Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Jing Huang,Yunyun Duan,Sidong Liu,et al.Altered Brain Structure and Functional Connectivity of Primary Visual Cortex in Optic Neuritis[J].FRONTIERS IN HUMAN NEUROSCIENCE.2018,12:-.doi:10.3389/fnhum.2018.00473.
APA：
Jing Huang,Yunyun Duan,Sidong Liu,Peipeng Liang,Zhuoqiong Ren...&Kuncheng Li.(2018).Altered Brain Structure and Functional Connectivity of Primary Visual Cortex in Optic Neuritis.FRONTIERS IN HUMAN NEUROSCIENCE,12,
MLA：
Jing Huang,et al."Altered Brain Structure and Functional Connectivity of Primary Visual Cortex in Optic Neuritis".FRONTIERS IN HUMAN NEUROSCIENCE 12.(2018):-
