机构：[a]Department of Radiology, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, P.R. China放射科首都医科大学宣武医院[b]Department of Neurology, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, P.R. China神经内科首都医科大学宣武医院[c]Beijing Institute of Geriatrics, Beijing 100053, P.R. China[d]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, P.R. China
A selective distribution of Alzheimer's disease (AD) pathological lesions in specific cortical layers isolates the hippocampus from the rest of the brain. However, functional connectivity between the hippocampus and other brain regions remains unclear in AD. Here, we employ a resting state functional NM (fMRI) to examine changes in hippocampal connectivity comparing 13 patients with mild AD versus 13 healthy age-matched controls. Hippocampal connectivity was investigated by examination of the correlation between low frequency fMRI signal fluctuations in the hippocampus and those in all other brain regions. We found that functional connectivity between the right hippocampus and a set of regions was disrupted in AD; these regions are: medial prefrontal cortex (MPFC), ventral anterior cingulate cortex (vACC), right inferotemporal cortex, right cuneus extending into precuneus, left cuneus, right superior and middle temporal gyros and posterior cingulate cortex (PCC). We also found increased functional connectivity between the left hippocampus and the right lateral prefrontal cortex in AD. In addition, rightward asymmetry of hippocampal connectivity observed in elderly controls was diminished in AD patients. The disrupted hippocampal connectivity to the MPFC, vACC and PCC provides further support for decreased activity in "default mode network" previously shown in AD. The decreased connectivity between the hippocampus and the visual cortices might indicate reduced integrity of hippocampus-related cortical networks in AD. Moreover, these findings suggest that resting-state fMRI might be an appropriate approach for studying pathophysiological changes in early AD. (c) 2005 Elsevier Inc. All rights reserved.
基金：
Foundation of Beijing Brain Aging Key Laboratory, Grant No. 951890600, the Natural Science Foundation of China, Grant Nos. 30425004 and 60121302,
and the National Key Basic Research and Development Program (973) Grant No. 2004CB318107
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2005]版：
大类|2 区医学
最新[2023]版：
大类|2 区医学
小类|1 区神经成像2 区神经科学2 区核医学
JCR分区：
出版当年[2004]版：
Q1NEUROIMAGINGQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGINGQ1NEUROSCIENCES
最新[2023]版：
Q1NEUROIMAGINGQ1NEUROSCIENCESQ1RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
第一作者机构：[a]Department of Radiology, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, P.R. China
通讯作者：
通讯机构：[a]Department of Radiology, Xuanwu Hospital of Capital University of Medical Sciences, Beijing 100053, P.R. China[d]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, P.R. China
推荐引用方式(GB/T 7714)：
Liang Wang ,Yufeng Zang ,Yong He ,et al.Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI[J].NEUROIMAGE.2006,31(2):496-504.doi:10.1016/j.neuroimage.2005.12.033.
APA：
Liang Wang,,Yufeng Zang,,Yong He,,Meng Liang,,Xinqing Zhang,...&Kuncheng Li.(2006).Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI.NEUROIMAGE,31,(2)
MLA：
Liang Wang,,et al."Changes in hippocampal connectivity in the early stages of Alzheimer's disease: Evidence from resting state fMRI".NEUROIMAGE 31..2(2006):496-504
医学