机构：[1]Department of Radiology & Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi’an, China,[2]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing, China,神经内科首都医科大学宣武医院[3]Department of Medical Image Diagnosis, Hanzhong Central Hospital, Hanzhong, China,[4]Student Brigade, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi’an, China
Aims: To investigate the white matter (WM) integrity and hippocampal functional connectivity (FC) in type 2 diabetes mellitus (T2DM) patients without mild cognitive impairment (MCI) by using diffusion tensor imaging (DTI) and resting-state functional magnetic resonance imaging (rs-fMRI), respectively. Methods: Twelve T2DM patients without MCI and 24 age, sex and education matched healthy controls (HC) were recruited. DTI and rs-fMRI data were subsequently acquired on a 3.0T MR scanner. Tract-based spatial statistics (TBSS) combining region of interests (ROIs) analysis was used to investigate the alterations of DTI metrics (fractional anisotropy (FA), mean diffusivity (MD), lambda(1) and lambda(23)) and FC measurement was performed to calculate hippocampal FC with other brain regions. Cognitive function was evaluated by using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). Brain volumes were also evaluated among these participants. Results: There were no difference of MMSE and MoCA scores between two groups. Neither whole brain nor regional brain volume decrease was revealed in T2DM patients without MCI. DTI analysis revealed extensive WM disruptions, especially in the body of corpus callosum (CC). Significant decreases of hippocampal FC with certain brain structures were revealed, especially with the bilateral frontal cortex. Furthermore, the decreased FA in left posterior thalamic radiation (PTR) and increased MD in the splenium of CC were closely related with the decreased hippocampal FC to caudate nucleus and frontal cortex. Conclusions: T2DM patients without MCI showed extensive WM disruptions and abnormal hippocampal FC. Moreover, the WM disruptions and abnormal hippocampal FC were closely associated. Highlights - T2DM patients without MCI demonstrated no obvious brain volume decrease. - Extensive white matter disruptions, especially within the body of corpus callosum, were revealed with DTI analysis among the T2DM patients. - Despite no MCI in T2DM patients, decreased functional connectivity between hippocampal region and some critical brain regions were detected. - The alterations in hippocampal functional connectivity were closely associated with those of the white matter structures in T2DM patients.
基金：
the National Natural Science Foundation of China (No. 81471636 and No. 61603399).
第一作者机构：[1]Department of Radiology & Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi’an, China,
通讯作者：
通讯机构：[1]Department of Radiology & Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital, The Military Medical University of PLA Airforce (Fourth Military Medical University), Xi’an, China,[2]Department of Neurology, XuanWu Hospital, Capital Medical University, Beijing, China,
推荐引用方式(GB/T 7714)：
Qian Sun,Guan-Qun Chen,Xi-Bin Wang,et al.Alterations of White Matter Integrity and Hippocampal Functional Connectivity in Type 2 Diabetes Without Mild Cognitive Impairment[J].FRONTIERS IN NEUROANATOMY.2018,12:doi:10.3389/fnana.2018.00021.
APA：
Qian Sun,Guan-Qun Chen,Xi-Bin Wang,Ying Yu,Yu-Chuan Hu...&Guang-Bin Cui.(2018).Alterations of White Matter Integrity and Hippocampal Functional Connectivity in Type 2 Diabetes Without Mild Cognitive Impairment.FRONTIERS IN NEUROANATOMY,12,
MLA：
Qian Sun,et al."Alterations of White Matter Integrity and Hippocampal Functional Connectivity in Type 2 Diabetes Without Mild Cognitive Impairment".FRONTIERS IN NEUROANATOMY 12.(2018)
医学