Background: Although Bone morphogenetic protein-2 (BMP-2) is a known mediator of bone regeneration and vascular calcification, to date no study has investigated the relationship between BMP-2 and type 2 diabetes mellitus (T2DM) and its possible role in coronary artery disease (CAD). The purpose of this study is to evaluate the relationship of BMP-2 with atherosclerosis and calcification in patients with T2DM. Methods: 124 subjects were enrolled in this study: 29 patients with T2DM and CAD; 26 patients with T2DM and without CAD; 36 patients with CAD and without T2DMand 34 without T2DM or CAD (control group). Severity of coronary lesions was assessed using coronary angiography and intravascular ultrasound (IVUS). Plasma BMP-2 levels were quantified using a commercially available ELISA kit. Results: Compared to the control group, the mean plasma BMP-2 level was significantly higher in T2DM patients with or without CAD (20.1 +/- 1.7 or 19.3 +/- 1.5 pg/ml, vs 17.2 +/- 3.3 pg/ml, P < 0.001). In a multivariable linear regression analysis, both T2DM and CAD were significantly and positively associated with BMP-2 (Estimate, 0.249; standard error (SE), 0.063; p < 0.0001; Estimate, 0.400; SE, 0.06; p < 0.0001). Plasma BMP-2 was also strongly correlated with glycosylated hemoglobin A1c (HbA1c) (Spearman rho = -0.31; p = 0.0005). SYNTAX score was also significantly associated with BMP-2 (Spearman rho = 0.46; p = 0.0002). Using the results from IVUS, plasma BMP-2 levels were shown to positively correlate with plaque burden (Spearman rho = 0.38, P = 0.002) and plaque calcification (Spearman rho = 0.44, P = 0.0003) and to negatively correlate with lumen volume (Spearman rho = 0.31, P = 0.01). Conclusions: Our study demonstrates that patients with T2DM had higher circulating levels of BMP-2 than normal controls. Plasma BMP-2 levels correlated positively with plaque burden and calcification in patients with T2DM.
基金：
Chinese National Natural and Scientific Funding [81441012]; Beijing Natural Science FoundationBeijing Natural Science Foundation [7132088]; Beijing Novel Star Project on Science and Technology of China [2009B38]; Beijing Municipal Training Foundation for Highly-qualified and Technological Talents of Health System [2014-3-038]
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2014]版：
大类|2 区医学
小类|3 区心脏和心血管系统3 区内分泌学与代谢
最新[2023]版：
大类|1 区医学
小类|1 区心脏和心血管系统1 区内分泌学与代谢
JCR分区：
出版当年[2013]版：
Q2ENDOCRINOLOGY & METABOLISMQ2CARDIAC & CARDIOVASCULAR SYSTEMS
第一作者机构：[1]Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China;[2]Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China;
通讯作者：
通讯机构：[1]Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing 100029, Peoples R China;[2]Beijing Inst Heart Lung & Blood Vessel Dis, Beijing, Peoples R China;
推荐引用方式(GB/T 7714)：
Zhang Ming,Sara Jaskanwal Deep,Wang Fei-long,et al.Increased plasma BMP-2 levels are associated with atherosclerosis burden and coronary calcification in type 2 diabetic patients[J].CARDIOVASCULAR DIABETOLOGY.2015,14(1):-.doi:10.1186/s12933-015-0214-3.
APA：
Zhang, Ming,Sara, Jaskanwal Deep,Wang, Fei-long,Liu, Li-Ping,Su, Li-Xiao...&Liu, Jing-hua.(2015).Increased plasma BMP-2 levels are associated with atherosclerosis burden and coronary calcification in type 2 diabetic patients.CARDIOVASCULAR DIABETOLOGY,14,(1)
MLA：
Zhang, Ming,et al."Increased plasma BMP-2 levels are associated with atherosclerosis burden and coronary calcification in type 2 diabetic patients".CARDIOVASCULAR DIABETOLOGY 14..1(2015):-
医学