机构：[1]China–America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院中美神经科学研究所[2]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Beijing, China[3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China[4]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA[5]Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA[6]Department of Neurosurgery, XuanWu Hospital, Capital Medical University, Beijing, China神经外科首都医科大学宣武医院
To bridge the gap between rodent and human studies, the Stroke Therapy Academic Industry Roundtable committee suggests that nonhuman primates (NHPs) be used for preclinical, translational stroke studies. Owing to the fact that vast majority of ischemic strokes are caused by transient or permanent occlusion of a cerebral blood vessel eventually leading to brain infarction, ischemia induced by endovascular methods closely mimics thromboembolic or thrombotic cerebrovascular occlusion in patients. This review will make a thorough summary of transient or permanent occlusions of a cerebral blood vessel in NHPs using endovascular methods. Then, advantages and disadvantages, and potential applications will be analyzed for each kind of models. Additionally, we also make a further analysis based on different kinds of emboli, various occlusion sites, infract size, abnormal hemodynamics, and potential dysfunctions. Experimental models of ischemic stroke in NHPs are valuable tools to analyze specific facets of stroke in patients, especially those induced by endovascular methods.
基金：
National Natural Science Foundation of China for Outstanding Youth (81325007);
National Natural Science Foundation of China (81500997, 81771260);
Chang Jiang Scholars Program (#T2014251) from the Chinese Ministry of Education;
National Natural Science Foundation of China (81620108011) ;
Nationa l Key R&D Program of China (2017YFC1308401);
the "mission" talent project of Beijing Municipal Administration of Hospitals (SML20150802);
Beijing Municipal Administration of Hospitals’ Youth Programme (QML20170802).
第一作者机构：[1]China–America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Beijing, China[3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
通讯作者：
通讯机构：[1]China–America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China[2]Beijing Key Laboratory of Hypoxia Conditioning Translational Medicine, Beijing, China[3]Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
推荐引用方式(GB/T 7714)：
Di Wu,Ankush Chandra,Jian Chen,et al.Endovascular Ischemic Stroke Models in Nonhuman Primates[J].NEUROTHERAPEUTICS.2018,15(1):146-155.doi:10.1007/s13311-017-0586-z.
APA：
Di Wu,Ankush Chandra,Jian Chen,Yuchuan Ding&Xunming Ji.(2018).Endovascular Ischemic Stroke Models in Nonhuman Primates.NEUROTHERAPEUTICS,15,(1)
MLA：
Di Wu,et al."Endovascular Ischemic Stroke Models in Nonhuman Primates".NEUROTHERAPEUTICS 15..1(2018):146-155
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