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Serum neuron specific enolase may be a marker to predict the severity and outcome of cerebral venous thrombosis

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机构： [1]Departments of Neurology, Neurosurgery, Ophthalmology and Emergency, Xuanwu Hospital, Capital Medical University, Beijing Institute for Brain Disorders, Beijing 100053, China [2]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI 48201, USA

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关键词： Serum neuron specific enolase Cerebral venous thrombosis Severity Outcome

摘要：

The objective is to explore the effective of baseline serum neuron specific enolase (NSE) on predicting the severity and outcome in patients with cerebral venous thrombosis (CVT). A total of 156 patients confirmed as CVT in Xuanwu Hospital were enrolled in this retrospective study from March 2011 through September 2016. The severity was evaluated with the National Institutes of Health Stroke Score (NIHSS), intracranial pressure (ICP), and CVT-related complications; the outcome was evaluated by modified Rankin Scale (mRS); the relationship between baseline serum NSE and mRS was analyzed with receiver operating characteristic curve (ROC), logistic regression analysis, and Kaplan-Meier curves. Baseline level of serum NSE was positively associated with baseline NIHSS (r = 0.322, p < 0.001). Among which, patients with high level of serum NSE were also noticed with cerebral venous infarction (p < 0.001), intracranial hemorrhage (p < 0.001), seizure (p = 0.035). Meanwhile, patients in NSE >= 15.05 ng/mL group vs. NSE < 15.05 ng/mL group had large mRS scores (>= 3) at discharge (adjusted OR: 5.40, 95% CI 1.27-22.91; p = 0.022) and higher percentage of mRS scores >= 3 during 40 months of outpatient follow-up (log-rank p < 0.001). Baseline level of serum NSE is positively associated with the severity of CVT. Presumably NSE may be a potential predictor for the clinical outcome of CVT.

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出版当年[2017]版：

大类 | 2 区医学

小类 | 3 区临床神经病学

最新[2023]版：

大类 | 2 区

医学

小类 | 2 区临床神经病学

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出版当年[2016]版：

Q2 CLINICAL NEUROLOGY

最新[2023]版：

Q1 CLINICAL NEUROLOGY

影响因子： 4.8 最新[2023版] 4.8 最新五年平均 3.389 出版当年[2016版] 3.652 出版当年五年平均 3.408 出版前一年[2015版] 3.783 出版后一年[2017版]

第一作者：

第一作者机构： [1]Departments of Neurology, Neurosurgery, Ophthalmology and Emergency, Xuanwu Hospital, Capital Medical University, Beijing Institute for Brain Disorders, Beijing 100053, China

通讯作者：

通讯机构： [1]Departments of Neurology, Neurosurgery, Ophthalmology and Emergency, Xuanwu Hospital, Capital Medical University, Beijing Institute for Brain Disorders, Beijing 100053, China

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