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Anticoagulation delay does not affect the functional outcome of cerebral venous thrombosis

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机构： [1]China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [2]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [3]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

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关键词： Anticoagulation delay Headache Outcome Sinus thrombosis

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Available knowledge about the impact of anticoagulation delay on outcomes of patients with cerebral venous thrombosis (CVT) is limited. We therefore assessed the factors influencing anticoagulation delay and investigated the effect of this delay on outcomes of CVT patients. Anticoagulation delay was defined as the time interval between symptom onset and anticoagulation initiation. The primary outcome was a modified Rankin Scale (mRS) score > 2 at the final follow-up. A total of 164 eligible patients were included. The median anticoagulation delay was 9 days. Cerebral hemorrhage on admission neuroimaging correlated with earlier anticoagulation (p = 0.040). Anticoagulation delay was not associated with poor functional outcome (mRS > 2), but it was associated with residual headache across the entire cohort (earlier anticoagulation: 15/76 [19.7%] vs. later anticoagulation: 28/79 [35.4%]; p = 0.029) and in the subgroup with isolated intracranial hypertension (earlier anticoagulation: 4/25 [16.0%] vs. later anticoagulation: 14/27 [51.9%]; p = 0.007). Anticoagulation delay was found to be common among patients with CVT. Anticoagulation delay was not associated with poor functional outcome, but may have led to an increased risk of residual headache across our entire cohort and in the subgroup with isolated intracranial hypertension. © Ji et al.

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出版当年[2019]版：

大类 | 2 区医学

小类 | 2 区老年医学 3 区细胞生物学

最新[2023]版：

大类 | 3 区医学

小类 | 3 区细胞生物学 3 区老年医学

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出版当年[2018]版：

Q1 GERIATRICS & GERONTOLOGY Q1 CELL BIOLOGY

最新[2023]版：

Q2 CELL BIOLOGY Q2 GERIATRICS & GERONTOLOGY

影响因子： 3.9 最新[2023版] 4.9 最新五年平均 5.515 出版当年[2018版] 5.543 出版当年五年平均 5.179 出版前一年[2017版] 4.831 出版后一年[2019版]

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第一作者机构： [1]China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [2]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

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