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Co-delivery of tumor-derived exosomes with alpha-galactosylceramide on dendritic cell-based immunotherapy for glioblastoma

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WOS体系：

收录情况： ◇ SCIE

作者：
Hongyu Liu [a] * ; Ling Chen [a] * ; Jialin Liu [a] * ; Hengxing Meng [a] ; Rong Zhang [b] ; Lin Ma [c] ; Liangliang Wu [d] ; Songyan Yu [e] ; Fei Shi [f] ; Ying Li [c] ; Lijun Zhang [d] ; Lingxiong Wang [d] ; Shiyu Feng [a] ; Qi Zhang [e] ; Yaojun Peng [d] ; Qiyan Wu [d] ; Chunxi Liu [d] ; Xin Chang [g] ; Lin Yang [a] ; Yasushi Uemura [b] ; Xinguang Yu [a] ; Tianyi Liu [d] ;
机构： [a]Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China [b]Division of Cancer Immunotherapy, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Chiba 277-8577, Japan [c]Department of Radiology, Chinese PLA General Hospital, Beijing 100853, China [d]Key Laboratory of Cancer Center, Chinese PLA General Hospital, Beijing 100853, China [e]Department of Endocrinology, Chinese PLA General Hospital, Beijing 100853, China [f]Department of Skull Base Surgery Center, Otorhinolaryngology Head and Neck Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [g]Department of Clinical Laboratory, Weihai Municipal Hospital, Weihai 264200, China
出处：
DOI： 10.1016/j.canlet.2017.09.022
ISSN：

关键词： Glioblastoma multiforme Exosome Dendritic cells Invariant natural killer T cells Immunotherapy

摘要：
Dendritic cell (DC) vaccine-based immunotherapy for glioblastoma multiforme (GBM) has shown apparent benefit in animal experiments and early-phase clinical trials, but the survival benefit is variable. In this work, we analyzed the mechanism of the potent antitumor immune response induced in vivo by tumor-associated antigen (TAA)-specific DCs with an invariant natural killer T (iNKT) cell adjuvant in orthotopic glioblastoma-bearing rats vaccinated with tumor-derived exosomes and alpha-galactosylceramide (alpha-GalCer)-pulsed DCs. Compared with traditional tumor lysate, exosomes were utilized as a more potent antigen to load DCs. iNKT cells, as an effective cellular adjuvant activated by alpha-GalCer, strengthened TAA presentation through their interaction with DCs. Co-delivery of tumor-derived exosomes with alpha-GalCer on a DC-based vaccine showed powerful effects in glioblastoma immunotherapy. This vaccine induced strong activation and proliferation of tumor-specific cytotoxic T lymphocytes, synergistically breaking the immune tolerance and improving the immunosuppressive environment. (c) 2017 Elsevier B.V. All rights reserved.

基金：
the National Natural Science Foundation of China (grant nos. 81272804 and 81672824) the National Key Technology Research and Development Program of the Ministry of Science and Technology of China (grant no. 2014BAI04B02).
语种：
外文
被引次数：
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PubmedID：
中科院(CAS)分区：
出版当年[2016]版：
大类 | 2 区 医学
小类 | 2 区 肿瘤学
最新[2023]版：
大类 | 1 区 医学
小类 | 2 区 肿瘤学
JCR分区：
出版当年[2015]版：
Q1 ONCOLOGY
最新[2023]版：
Q1 ONCOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2015版] 出版当年五年平均 出版前一年[2014版] 出版后一年[2016版]

第一作者：
第一作者机构： [a]Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China
共同第一作者：
通讯作者：
通讯机构： [a]Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China [d]Key Laboratory of Cancer Center, Chinese PLA General Hospital, Beijing 100853, China
推荐引用方式(GB/T 7714)：
Hongyu Liu,Ling Chen,Jialin Liu,et al.Co-delivery of tumor-derived exosomes with alpha-galactosylceramide on dendritic cell-based immunotherapy for glioblastoma[J].CANCER LETTERS.2017,411:182-190.doi:10.1016/j.canlet.2017.09.022.
APA：
Hongyu Liu,Ling Chen,Jialin Liu,Hengxing Meng,Rong Zhang...&Tianyi Liu.(2017).Co-delivery of tumor-derived exosomes with alpha-galactosylceramide on dendritic cell-based immunotherapy for glioblastoma.CANCER LETTERS,411,
MLA：
Hongyu Liu,et al."Co-delivery of tumor-derived exosomes with alpha-galactosylceramide on dendritic cell-based immunotherapy for glioblastoma".CANCER LETTERS 411.(2017):182-190

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