Localizing the semiology of ictal fear and seizure onset in epilepsy patients is commonly challenging due to limited value of routine electroencephalography (EEG) and very few surgical attempts. Here we reported a case of refractory epilepsy characterized by aura of extreme fear and hypermotor seizures, in which the left (dominant hemisphere) anterior cingulate gyrus (ACG) was determined to be the epileptogenic zone (EZ) through multiple modalities of presurgical evaluation including analysis of high frequency oscillation on intracranial EEG. Tailored resection of EZ was thus performed and pathological examination revealed focal cortical dysplasia (FCD) type lib. The patient has been seizure free during an 18-month follow-up. The report has provided novel anatomical, electrophysiological and surgical evidences suggesting the critical role of ACG in ictal fear and possibility of surgical management of fear-manifesting refractory epilepsy.
第一作者机构：[1]Beijing Institute of Functional Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing 100053, China[*1]45 Changchun Street, Xicheng District, Beijing 100053 China.
Liang Qiao,Tao Yu ,Duanyu Ni ,et al.Correlation between extreme fear and focal cortical dysplasia in anterior cingulate gyrus: Evidence from a surgical case of refractory epilepsy[J].CLINICAL NEUROLOGY AND NEUROSURGERY.2017,163:121-123.doi:10.1016/j.clineuro.2017.10.025.
APA：
Liang Qiao,Tao Yu,,Duanyu Ni,,Xueyuan Wang,,Cuiping Xu,...&Yongjie Li.(2017).Correlation between extreme fear and focal cortical dysplasia in anterior cingulate gyrus: Evidence from a surgical case of refractory epilepsy.CLINICAL NEUROLOGY AND NEUROSURGERY,163,
MLA：
Liang Qiao,et al."Correlation between extreme fear and focal cortical dysplasia in anterior cingulate gyrus: Evidence from a surgical case of refractory epilepsy".CLINICAL NEUROLOGY AND NEUROSURGERY 163.(2017):121-123
