机构：[a]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[b]Department of Neurology, Mayo Clinic, Rochester, MN, USA
Monoclonal gammopathies due to plasma cell dyscrasias can induce diverse rare neuromuscular disorders. Deposition of monoclonal antibody light chains in skeletal muscle causes amyloid myopathy. Monoclonal gammopathy is occasionally associated with sporadic late-onset nemaline myopathy. Here we report a monoclonal gammopathy patient with both sporadic late-onset nemaline myopathy and amyloid myopathy. The diagnoses were based on immunofixation electrophoresis of urine, and serum for free light chain assay, Congo red staining and Thioflavin S staining of muscle biopsies, as well as immunohistochemical staining and electron-microscopic observation. Nemaline myopathy and amyloid myopathy can present in the same patient with monoclonal gammopathy. (C) 2017 Elsevier B.V. All rights reserved.
基金：
the Beijing Natural Science Foundation Program
Scientific Research Key Program of Beijing Municipal Commission of Education (No. KZ201410025023 toYD),
the National Science Foundation of China (No. 81071000 to YD).
第一作者机构：[a]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[*1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China.
推荐引用方式(GB/T 7714)：
Min Wang,Lin Lei,Hai Chen,et al.Monoclonal gammopathy with both nemaline myopathy and amyloid myopathy[J].NEUROMUSCULAR DISORDERS.2017,27(10):942-946.doi:10.1016/j.nmd.2017.05.007.
APA：
Min Wang,Lin Lei,Hai Chen,Li Di,Mi Pang...&Yuwei Da.(2017).Monoclonal gammopathy with both nemaline myopathy and amyloid myopathy.NEUROMUSCULAR DISORDERS,27,(10)
MLA：
Min Wang,et al."Monoclonal gammopathy with both nemaline myopathy and amyloid myopathy".NEUROMUSCULAR DISORDERS 27..10(2017):942-946
