机构：[1]Central Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081[2]Department of Oral Pathology, School and Hospital of Stomatology, Tongji University, Shanghai Engineering Research Center of Tooth Restoration and Regeneration, Shanghai 200072[3]Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University, Beijing 100191[4]Department of Orthodontics, Peking University School and Hospital of Stomatology, Beijing 100081[5]Department of Dentistry, Capital Medical University Xuanwu Hospital, Beijing 100053, P.R. China首都医科大学宣武医院
Cancer cell-derived immunoglobulin G (cancer-IgG) has been implicated in the pathogenesis and progression of various types of cancer. However, its role in salivary adenoid cystic carcinoma (SACC) remains unclear. The present study aimed to investigate the effects of cancer-IgG on metastasis and prognosis in 96 patients with SACC. Immunohistochemical staining showed that cancer-IgG expression was present in all 96 individual SACC tissues. Additionally, high cancer-IgG expression was significantly correlated with metastasis, nerve invasion and recurrence in SACC (P<0.05). Moreover, cancer-IgG expression was significantly correlated with the survival duration of patients with SACC (P<0.05). Proliferation, cell motility and invasion all decreased significantly following knockdown of cancer-IgG in SACC cells (P<0.05) through population-doubling time, wound healing and transwell invasion assays. Additionally, cancer-IgG-knockdown in SACC cells induced the increased expression of E-cadherin and matrix metalloproteinase 9, and promoted the epithelial-mesenchymal transition, but decreased the expression of F-actin filaments. Taken together, these results showed that the high expression of cancer-IgG was strongly associated with metastasis, recurrence and invasion in SACC, suggesting that cancer-IgG expression could serve as a useful biomarker to predict the prognosis of the disease.
基金：
the National Nature Science Foundation of China (grant nos. 81072214, 81171006 and 81272237).
第一作者机构：[1]Central Laboratory, Peking University School and Hospital of Stomatology, Beijing 100081
通讯作者：
通讯机构：[*1]Department of Immunology, Key Laboratory of Medical Immunology, Ministry of Health, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, P.R. China[*2]Central Laboratory, Peking University School and Hospital of Stomatology, 22 South Zhongguancun Avenue, Haidian, Beijing 100081, P.R. China
推荐引用方式(GB/T 7714)：
JING PENG,HAI CHENG WANG,YANG LIU,et al.Involvement of non-B cell-derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma[J].ONCOLOGY LETTERS.2017,14(4):4491-4498.doi:10.3892/ol.2017.6782.
APA：
JING PENG,HAI CHENG WANG,YANG LIU,JIU HUI JIANG,WAN QI LV...&XIAO YAN QIU.(2017).Involvement of non-B cell-derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma.ONCOLOGY LETTERS,14,(4)
MLA：
JING PENG,et al."Involvement of non-B cell-derived immunoglobulin G in the metastasis and prognosis of salivary adenoid cystic carcinoma".ONCOLOGY LETTERS 14..4(2017):4491-4498
