机构：[a]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China老年医学科首都医科大学宣武医院[b]Wincon TheraCells Biotechnologies Co., Ltd., 3 Gaoxin 3 Rd, Nanning 530003, Guangxi, China[c]Department of Bio-engineering, Guangxi Medical University, 22 Shuangyong Rd, Nanning 530021, Guangxi, China[d]Guangxi Dongya Center for Nonhuman Primate Research and Technical Development, 3 Gaoxin 3 Rd, Nanning 530003, Guangxi, China[e]Department of Neuroscience, University of Kentucky College of Medicine, Lexington, KY 40536, USA
Type 2 diabetes mellitus is the most common form of diabetes that occurs in both human and nonhuman primates. Although spontaneously diabetic nonhuman primates are used extensively in diabetic related research and are a proven valuable tool for the study of the natural history of diabetes, little is known about the key factors that can cause this metabolic disorder and the preventative measures that could be employed to minimize the consequences of diabetes. Using a model of developing and untreated diabetes, this study describes the effects of housing arrangement (socially group-versus individually single-housed), exercise, diet, age, and sex on fasting plasma glucose, key lipids associated with diabetes, and bodyweight in two large cohorts of nonhuman primates. Key findings include exercise/housing arrangement's contribution to significant differences in bodyweight, levels of fasting plasma glucose, total cholesterol, and high- and low-density lipoproteins. Age also had profound effects on glucose, triglyceride and high-density lipoproteins, particularly in single-caged animals. Moreover, females had higher fasting glucose, total cholesterol and triglyceride level's than male counterparts within the same housing situations. These factors may be critical to identifying preventive measures that could eventually be used to minimize obesity and diabetes in humans. (C) 2017 Elsevier Inc. All rights reserved.
基金：
National Natural Science Foundation of China(31472056),
the State High-Tech Development Plan of Ministry of Sciences and Technology of China (2012AA020703),
Projects (1598025-31, 20164412-3) of Science & Technology Department of Guangxi Province of China,
the Project (20155192, 20163349) of Science & Technology Bureau of Nanning of China.
第一作者机构：[a]Department of Neurobiology, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
共同第一作者：
通讯作者：
通讯机构：[*1]Dept. of Neuroscience, University of Kentucky, Chandler Medical Center, 48Whitney-Hendrickson Bldg, Lexington, KY 40536-0098, USA.
推荐引用方式(GB/T 7714)：
Feng Yue,Guodong Zhang,Jorge E. Quintero,et al.Role of social interaction, exercise, diet, and age on developing and untreated diabetes in cynomolgus monkeys[J].EXPERIMENTAL GERONTOLOGY.2017,96:82-88.doi:10.1016/j.exger.2017.06.010.
APA：
Feng Yue,Guodong Zhang,Jorge E. Quintero,Don M. Gash&Zhiming Zhang.(2017).Role of social interaction, exercise, diet, and age on developing and untreated diabetes in cynomolgus monkeys.EXPERIMENTAL GERONTOLOGY,96,
MLA：
Feng Yue,et al."Role of social interaction, exercise, diet, and age on developing and untreated diabetes in cynomolgus monkeys".EXPERIMENTAL GERONTOLOGY 96.(2017):82-88
