机构：[1]Department of Radiology, Xuanwu Hospital, Beijing, China放射科首都医科大学宣武医院[2]Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA[3]Department of Bioengineering, University of California, Los Angeles, California, USA[4]MR R&D, Siemens Healthcare, Los Angeles, California, USA[5]Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA[6]Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, California, USA
Purpose: To propose and evaluate a parameter tune-up solution to expedite a three-dimensional (3D) variable-flip-angle turbo spin-echo (TSE) sequence for whole-brain intracranial vessel wall (IVW) imaging. Materials and Methods: Elliptical k-space sampling and prolonged echo train length (ETL), were used to expedite a 3D variable-flip-angle TSE-based sequence. To compensate for the potential loss in vessel wall signal, optimal combination of prescribed T-2 and ETL was experimentally investigated on 22 healthy volunteers at 3 Tesla. The optimized protocol (7-8 min) was then compared with a previous protocol (reference protocol, 11-12 min) in terms of signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR), vessel wall sharpness, and wall delineation quality on a 4-point scale (0: poor; 3: excellent) in 10 healthy volunteers. A pilot study of five patients was performed and lesion delineation score was used to demonstrate the diagnostic quality. Results: A protocol with ETL = 52 and prescribed T-2 = 170 ms was deemed an optimized one, which, compared with the reference protocol, provided significantly improved wall SNR (12.0 +/- 1.3 versus 10.0 +/- 1.1; P = 0.002), wall-lumen CNR (9.7 +/- 1.2 versus 8.0 +/- 0.9; P = 0.002), wall-CSF CNR (2.8 +/- 1.0 versus 1.7 +/- 1.0; P = 0.026), similar vessel wall sharpness at both inner (1.59 +/- 0.18 versus 1.58 +/- 0.14, P = 0.87) and outer (1.71 +/- 0.25 versus 1.83 +/- 0.30; P = 0.18) boundaries, and comparable vessel wall delineation score for individual segments (1.95-3; P > 0.06). In all patients, atherosclerotic plaques (10) or wall dissection (5) were identified with a delineation score of 3 or 2. Conclusion: A parameter tune-up solution can accelerate 3D variable-flip-angle TSE acquisitions, particularly allowed for expedited whole-brain IVW imaging with preserved wall delineation quality.
基金：
American Heart Association; contract grant number: 15SDG25710441;
Contract grant sponsor:National Institutes of Health;
contract grant number:NHLBI 2R01HL096119;
Contract grant sponsor: National Science Foundation of China;
contract grant number: No.81325007; Contract grant number: 81322022;
Contract grant sponsor: Program for New Century Excellent Talents in University; contract grant number: No. 13-0918.
第一作者机构：[1]Department of Radiology, Xuanwu Hospital, Beijing, China[2]Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA
共同第一作者：
通讯作者：
通讯机构：[*1]Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, 8700 Beverly Blvd., PACT 800, Los Angeles, CA 90048.
推荐引用方式(GB/T 7714)：
Qi Yang ,Zixin Deng ,Xiaoming Bi ,et al.Whole-Brain Vessel Wall MRI: A Parameter Tune-up Solution to Improve the Scan Efficiency of Three-Dimensional Variable Flip-Angle Turbo Spin-Echo[J].JOURNAL OF MAGNETIC RESONANCE IMAGING.2017,46(3):751-757.doi:10.1002/jmri.25611.
APA：
Qi Yang,,Zixin Deng,,Xiaoming Bi,,Shlee S. Song,,Konrad H. Schlick,...&Zhaoyang Fan,.(2017).Whole-Brain Vessel Wall MRI: A Parameter Tune-up Solution to Improve the Scan Efficiency of Three-Dimensional Variable Flip-Angle Turbo Spin-Echo.JOURNAL OF MAGNETIC RESONANCE IMAGING,46,(3)
MLA：
Qi Yang,,et al."Whole-Brain Vessel Wall MRI: A Parameter Tune-up Solution to Improve the Scan Efficiency of Three-Dimensional Variable Flip-Angle Turbo Spin-Echo".JOURNAL OF MAGNETIC RESONANCE IMAGING 46..3(2017):751-757
