机构：[1]Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.[2]Department of Radiology, Xuanwu Hospital, Beijing, China.放射科首都医科大学宣武医院[3]Department of Bioengineering, University of California, Los Angeles, California, USA.[4]Department of Neurology, Xuanwu Hospital, Beijing, China.神经内科首都医科大学宣武医院[5]MR R&D, Siemens Healthcare, Los Angeles, California, USA.[6]Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Purpose: Although three-dimensional (3D) turbo spin echo (TSE) with variable flip angles has proven to be useful for intracranial vessel wall imaging, it is associated with inadequate suppression of cerebrospinal fluid (CSF) signals and limited spatial coverage at 3 Tesla (T). This work aimed to modify the sequence and develop a protocol to achieve whole-brain, CSF-attenuated T-1-weighted vessel wall imaging. Methods: Nonselective excitation and a flip-down radiofrequency pulse module were incorporated into a commercial 3D TSE sequence. A protocol based on the sequence was designed to achieve T-1-weighted vessel wall imaging with whole-brain spatial coverage, enhanced CSF-signal suppression, and isotropic 0.5-mm resolution. Human volunteer and pilot patient studies were performed to qualitatively and quantitatively demonstrate the advantages of the sequence. Results: Compared with the original sequence, the modified sequence significantly improved the T-1-weighted image contrast score (2.0760.19 versus 3.0060.00, P = 0.011), vessel wall-toCSF contrast ratio (0.1460.16 versus 0.5260.30, P = 0.007) and contrast-to-noise ratio (1.6962.18 versus 4.2662.30, P = 0.022). Significant improvement in vessel wall outer boundary sharpness was observed in severalmajor arterial segments. Conclusions: The new 3D TSE sequence allows for highquality T-1-weighted intracranial vessel wall imaging at 3 T. It may potentially aid in depicting small arteries and revealing T-1-mediated high-signal wall abnormalities. (C) 2016 International Society for Magnetic Resonance in Medicine
基金：
American Heart Association [15SDG25710441]; National Institutes of Health [NHLBI 2R01HL096119]; National Science Foundation of China [81322022, 81325007]; New Century Excellent Talents in University [13-0918]
第一作者机构：[1]Biomedical Imaging Research Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.[*1]Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., PACT 800, Los Angeles, CA 90048.
共同第一作者：
通讯作者：
通讯机构：[*1]Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd., PACT 800, Los Angeles, CA 90048.
推荐引用方式(GB/T 7714)：
Zhaoyang Fan ,Qi Yang ,Zixin Deng ,et al.Whole-Brain Intracranial Vessel Wall Imaging at 3 Tesla Using Cerebrospinal Fluid-Attenuated T1-Weighted 3D Turbo Spin Echo[J].MAGNETIC RESONANCE IN MEDICINE.2017,77(3):1142-1150.doi:10.1002/mrm.26201.
APA：
Zhaoyang Fan,,Qi Yang,,Zixin Deng,,Yuxia Li,,Xiaoming Bi,...&Debiao Li1,.(2017).Whole-Brain Intracranial Vessel Wall Imaging at 3 Tesla Using Cerebrospinal Fluid-Attenuated T1-Weighted 3D Turbo Spin Echo.MAGNETIC RESONANCE IN MEDICINE,77,(3)
MLA：
Zhaoyang Fan,,et al."Whole-Brain Intracranial Vessel Wall Imaging at 3 Tesla Using Cerebrospinal Fluid-Attenuated T1-Weighted 3D Turbo Spin Echo".MAGNETIC RESONANCE IN MEDICINE 77..3(2017):1142-1150
医学