Chronic Monoarthritis Pain Accelerates the Processes of Cognitive Impairment and Increases the NMDAR Subunits NR2B in CA3 of Hippocampus from 5-month-old Transgenic APP/PS1 Mice
机构：[1]Central Laboratory, Xuanwu Hospital of Capital Medical University, Laboratory for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China,首都医科大学宣武医院[2]Department of Pain Management, Xuanwu Hospital, Capital Medical University, Beijing, China,疼痛科首都医科大学宣武医院[3]Department of Anesthesiology, Fujian Medical University Union Hospital, Fuzhou, China
Many factors impact cognitive impairment; however, the effects of chronic pain and the mechanisms underlying these effects on cognitive impairment are currently unknown. Here we tested the hypothesis that chronic pain accelerates the transition from normal cognition to mild cognitive impairment (MCI) in 5-month-old transgenic APP/PS1 mice, an animal model of Alzheimer's disease (AD), and that neurotoxicity induced by N-methyl-D-aspartic acid receptor (NMDAR) subunits may be involved in this process. Chronic monoarthritis pain was induced in transgenic APP/PS1 mice and 5-month-old wild-type (WT) mice by intra-and pre-articular injections of Freund's complete adjuvant (FCA) into one knee joint. Pain behavior, learning and memory function, and the distribution and quantity of NMDAR subunits (NR1, NR2A and NR2B) in hippocampal CA1 and CA3 regions were assessed. Our results showed that although persistent and robust monoarthritis pain was induced by the FCA injections, only the transgenic APP/PS1 mice with chronic monoarthritis pain exhibited marked learning and memory impairments. This result suggested that chronic monoarthritis pain accelerated the cognitive impairment process. Furthermore, only transgenic APP/PS1 mice with chronic monoarthritis pain exhibited an overexpression of NR2B and an increased NR2B/NR2A ratio in the hippocampus CA3. These findings suggest that chronic pain is a risk factor for cognitive impairment and that increased neurotoxicity associated with NMDAR subunit activation may underpin the impairment. Thus, NMDARs may be a therapeutic target for the prevention of chronic pain-induced cognitive impairment.
基金：
the Fujian Health Young Cultivation Project Foundation (grant no. 2015-ZQN-JC-15),
the Beijing Postdoctoral Research Foundation,
the National Natural Science Foundation of China (grant no. 81472007),
the Capital Health Research and Development of Special (grant no. 2014-1-1031).
第一作者机构：[1]Central Laboratory, Xuanwu Hospital of Capital Medical University, Laboratory for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China,[2]Department of Pain Management, Xuanwu Hospital, Capital Medical University, Beijing, China,[3]Department of Anesthesiology, Fujian Medical University Union Hospital, Fuzhou, China
通讯作者：
通讯机构：[1]Central Laboratory, Xuanwu Hospital of Capital Medical University, Laboratory for Neurodegenerative Disease of Ministry of Education, Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China,
推荐引用方式(GB/T 7714)：
Wei-Yi Gong,Rong Wang,Yuan Liu,et al.Chronic Monoarthritis Pain Accelerates the Processes of Cognitive Impairment and Increases the NMDAR Subunits NR2B in CA3 of Hippocampus from 5-month-old Transgenic APP/PS1 Mice[J].FRONTIERS IN AGING NEUROSCIENCE.2017,9(MAY):123.doi:10.3389/fnagi.2017.00123.
APA：
Wei-Yi Gong,Rong Wang,Yuan Liu,He Jin,Zhi-Wei Zhao...&Jia-Xiang Ni.(2017).Chronic Monoarthritis Pain Accelerates the Processes of Cognitive Impairment and Increases the NMDAR Subunits NR2B in CA3 of Hippocampus from 5-month-old Transgenic APP/PS1 Mice.FRONTIERS IN AGING NEUROSCIENCE,9,(MAY)
MLA：
Wei-Yi Gong,et al."Chronic Monoarthritis Pain Accelerates the Processes of Cognitive Impairment and Increases the NMDAR Subunits NR2B in CA3 of Hippocampus from 5-month-old Transgenic APP/PS1 Mice".FRONTIERS IN AGING NEUROSCIENCE 9..MAY(2017):123
