机构：[1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China,神经内科首都医科大学宣武医院[2]Collaborative Innovation Center for Language Competence, Jiangsu Normal University, Xuzhou, China,[3]Department of Psychosomatic Medicine, University of Rostock, Rostock, Germany,[4]German Center for Neurodegenerative Disorders, Rostock, Germany,[5]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China,[6]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Geriatric Cognitive Disorders, Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing, China
Cholinergic deficiency has been implicated in the pathogenesis of vascular cognitive impairment (VCI), but the extent of involvement and underlying mechanism remain unclear. In this study, targeting the early stage of VCI, we determined regional atrophy within the basal forebrain and deficiency in cholinergic pathways in 25 patients with vascular cognitive impairment no dementia (VCIND) compared to 24 healthy elderly subjects. By applying stereotaxic cytoarchitectonic maps of the nucleus basalis of Meynert (NbM), no significant atrophy was identified in VCIND. Using probabilistic tractography analysis, our study tracked the two major white matter tracks which map to cholinergic pathways. We identified significantly lower fractional anisotropy (FA) in VCIND. Mediation analysis demonstrated that FA in the tracked pathways could fully account for the executive dysfunction, and partly mediate the memory and global cognition impairment. Our study suggests that the fibers mapped to the cholinergic pathways, but not the NbM, are significantly impaired in VCIND. MRI-based in vivo tracking of cholinergic pathways together with NbM measurement may become a valuable in vivo marker for evaluating the cholinergic system in cognitive disorders.
基金：
the National Natural Science Foundation of China [grant numbers 81671040, 31571156];
Beijing Municipal Science and Technology Commission [grant number Z151100004015078];
Key Medical Professional Development Plan of Beijing Municipal Administration of Hospitals [grant number ZYLX201301]
Beijing Talents Fund [grant number 2014000021223ZK31].
第一作者机构：[1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China,
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, Beijing, China,[5]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China,[6]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Geriatric Cognitive Disorders, Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing, China
推荐引用方式(GB/T 7714)：
Qing Liu,Zude Zhu,Stefan J. Teipel,et al.White Matter Damage in the Cholinergic System Contributes to Cognitive Impairment in Subcortical Vascular Cognitive Impairment, No Dementia[J].FRONTIERS IN AGING NEUROSCIENCE.2017,9(FEB):47.doi:10.3389/fnagi.2017.00047.
APA：
Qing Liu,Zude Zhu,Stefan J. Teipel,Jianwei Yang,Yi Xing...&Jianping Jia.(2017).White Matter Damage in the Cholinergic System Contributes to Cognitive Impairment in Subcortical Vascular Cognitive Impairment, No Dementia.FRONTIERS IN AGING NEUROSCIENCE,9,(FEB)
MLA：
Qing Liu,et al."White Matter Damage in the Cholinergic System Contributes to Cognitive Impairment in Subcortical Vascular Cognitive Impairment, No Dementia".FRONTIERS IN AGING NEUROSCIENCE 9..FEB(2017):47
