The efficacy of Cognitive training in patients with VAsCular Cognitive Impairment, No dEmentia (the Cog-VACCINE study): study protocol for a randomized controlled trial
机构：[1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.神经内科首都医科大学宣武医院[2]Collaborative Innovation Center for Language Competence, Jiangsu Normal University, Xuzhou, Jiangsu, China.[3]Department of Geriatric Medicine, Fu Xing Hospital, Capital Medical University, Beijing, China.[4]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
Background: Vascular cognitive impairment, no dementia (VCIND) refers to cognitive deficits associated with underlying vascular causes that fall short of a dementia diagnosis. There is currently no treatment for VCIND. Computerized cognitive training, which has significantly improved cognitive function in healthy older adults and patients with cognitive impairment has not yet been applied to VCIND. Methods/Design: The proposed study is a three-center, double-blinded, randomized controlled trial that will include 60 patients with VCIND. The patients will be randomized to either a training or a control group. The intervention is internet-based cognitive training performed for 30 min over 35 sessions. Neuropsychological assessment and functional and structural MRI will be performed before and after 7 weeks training. Primary outcomes are global cognitive function and executive function. Secondary outcome measures are neuroplasticity changes measured by functional and structural MRI. Discussion: Applying an internet-based, multi-domain, adaptive program, this study aims to assess whether cognitive training improves cognitive abilities and neural plasticity in patients with subcortical VCIND. In addition to the comprehensive assessment of the participants by neuropsychological tests, cerebrovascular risk factors and apolipoprotein E genotyping, neuroplasticity will be used as an evaluation outcome in this study for, to our knowledge, the first time. The combination of functional and structural MRI and neuropsychological tests will have strong sensitivity in evaluating the effects of cognitive training and will also reveal the underlying mechanisms at work.
基金：
Beijing Municipal Science & Technology Commission(Z151100004015078),
Beijing Talents Fund (2014000021223ZK31),
the National Natural Science Foundation of China (31571156).
第一作者机构：[1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Xuan Wu Hospital, Capital Medical University, 45 Changchun Street, Beijing 100053, China.[4]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Yi Tang,Zude Zhu,Qing Liu,et al.The efficacy of Cognitive training in patients with VAsCular Cognitive Impairment, No dEmentia (the Cog-VACCINE study): study protocol for a randomized controlled trial[J].TRIALS.2016,17(1):392.doi:10.1186/s13063-016-1523-x.
APA：
Yi Tang,Zude Zhu,Qing Liu,Fang Li,Jianwei Yang...&Jianping Jia.(2016).The efficacy of Cognitive training in patients with VAsCular Cognitive Impairment, No dEmentia (the Cog-VACCINE study): study protocol for a randomized controlled trial.TRIALS,17,(1)
MLA：
Yi Tang,et al."The efficacy of Cognitive training in patients with VAsCular Cognitive Impairment, No dEmentia (the Cog-VACCINE study): study protocol for a randomized controlled trial".TRIALS 17..1(2016):392
