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The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial

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资源类型：
WOS体系：
Pubmed体系：

收录情况： ◇ SCIE ◇ SSCI

作者：
Yi Tang[a,b,c] * ; Yi Xing[a,b,c] * ; Zude Zhu[d] ; Yong He[e,f,g] ; Fang Li[h] ; Jianwei Yang[a,b,c] ; Qing Liu[a,b] ; Fangyu Li[a,b,c] ; Stefan J. Teipel[i,j] ; Guoguang Zhao[k] ; Jianping Jia[a,b,c,l,m,n,o] ;
机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [b]Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China [c]Key Laboratory of Neurodegenerative Diseases, Ministry of Education of the People’s Republic of China, Beijing, China [d]Collaborative Innovation Center for Language Ability, Jiangsu Normal University, Xuzhou, China [e]State Key Laboratory of Cognitive Neuroscience and Learning, Beijing, China [f]Beijing Key Laboratory of Brain Imaging and Connectomics, Beijing, China [g]IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China [h]Department of Geriatric, Fu Xing Hospital, Capital Medical University, Beijing, China [i]Department of Psychosomatic Medicine, University Medicine Rostock, Rostock, Germany [j]DZNE, German Center for Neurodegenerative Diseases, Rostock, Germany [k]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [l]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China [m]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China [n]National Clinical Research Center for Geriatric Disorders, Beijing, China [o]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
出处：
DOI： 10.1016/j.jalz.2019.01.009
ISSN：

关键词： Brain plasticity Computerized cognitive training Randomized controlled trial Vascular cognitive impairment no dementia

摘要：
Introduction: Evidence for the efficacy of cognitive training in patients with subcortical vascular cognitive impairment no dementia is still lacking. Methods: A randomized, active controlled design using multidomain, adaptive, computerized cognitive training for 30 minutes, 5 days/week for 7 weeks. Assessments included global cognitive function and executive function (primary outcomes)and brain functional connectivity and structural changes (secondary outcomes). Results: Sixty patients were randomized across three medical centers in Beijing. At the end of the intervention, the cognitive training group showed significant improvement in Montreal Cognitive Assessment relative to the active control group (P =.013)and significantly increased functional connectivity between the left dorsolateral prefrontal cortex and medial prefrontal cortex, which was significantly correlated with Montreal Cognitive Assessment change (P =.017). Discussion: Computerized cognitive training significantly improved global cognitive function, which was supported by the improved brain plasticity. Incorporation of biomarkers should be implemented in cognitive training trials. © 2019 the Alzheimer's Association

基金：
国家自然科学基金
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2018]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学
最新[2023]版：
大类 | 1 区 医学
小类 | 1 区 临床神经病学
JCR分区：
出版当年[2017]版：
Q1 CLINICAL NEUROLOGY
最新[2023]版：
Q1 CLINICAL NEUROLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2017版] 出版当年五年平均 出版前一年[2016版] 出版后一年[2018版]

第一作者：
第一作者机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [b]Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China [c]Key Laboratory of Neurodegenerative Diseases, Ministry of Education of the People’s Republic of China, Beijing, China
共同第一作者：
通讯作者：
通讯机构： [a]Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China [b]Innovation Center for Neurological Disorders, Xuanwu Hospital, Capital Medical University, Beijing, China [c]Key Laboratory of Neurodegenerative Diseases, Ministry of Education of the People’s Republic of China, Beijing, China [k]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China [l]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing, China [m]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing, China [n]National Clinical Research Center for Geriatric Disorders, Beijing, China [o]Department of Neurology, Beijing Friendship Hospital, Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Yi Tang,Yi Xing,Zude Zhu,et al.The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial[J].ALZHEIMERS & DEMENTIA.2019,15(5):605-614.doi:10.1016/j.jalz.2019.01.009.
APA：
Yi Tang,Yi Xing,Zude Zhu,Yong He,Fang Li...&Jianping Jia.(2019).The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial.ALZHEIMERS & DEMENTIA,15,(5)
MLA：
Yi Tang,et al."The effects of 7-week cognitive training in patients with vascular cognitive impairment, no dementia (the Cog-VACCINE study): A randomized controlled trial".ALZHEIMERS & DEMENTIA 15..5(2019):605-614

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