机构：[1]College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, People’s Republic of China[2]Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, People’s Republic of China老年医学科首都医科大学宣武医院[3]Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, People’s Republic of China
Parkinson's disease (PD) is one of the most common neurodegenerative disorders in the world. Previous studies have focused on the basal ganglia and cerebral cortices. To date, the cerebellum has not been systematically investigated in patients with PD. In the current study, 45 probable PD patients and 40 age- and gender-matched healthy controls underwent structural magnetic resonance imaging, and we used support vector machines combining with voxel-based morphometry to explore the cerebellar structural changes in the probable PD patients relative to healthy controls. The results revealed that the gray matter alterations were primarily located within the cerebellar Crus I, implying a possible important role of this region in PD. Furthermore, the gray matter alterations in the cerebellum could differentiate the probable PD patients from healthy controls with accuracies of more than 95 % (p < 0.001, permutation test) via cross-validation, suggesting the potential of analyzing the cerebellum in the clinical diagnosis of PD.
基金：
the National Science Foundation of China (61503397, 61420106001, 61375111, and 61375034)
National High-tech Program of China (2012AA011601).
第一作者机构：[1]College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, People’s Republic of China
通讯作者：
通讯机构：[1]College of Mechatronics and Automation, National University of Defense Technology, Changsha, Hunan 410073, People’s Republic of China[2]Department of Neurobiology, Key Laboratory on Neurodegenerative Disorders of Ministry of Education, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, People’s Republic of China
推荐引用方式(GB/T 7714)：
Ling-Li Zeng,Liang Xie,Hui Shen,et al.Differentiating Patients with Parkinson's Disease from Normal Controls Using Gray Matter in the Cerebellum[J].CEREBELLUM.2017,16(1):151-157.doi:10.1007/s12311-016-0781-1.
APA：
Ling-Li Zeng,Liang Xie,Hui Shen,Zhiguo Luo,Peng Fang...&Dewen Hu.(2017).Differentiating Patients with Parkinson's Disease from Normal Controls Using Gray Matter in the Cerebellum.CEREBELLUM,16,(1)
MLA：
Ling-Li Zeng,et al."Differentiating Patients with Parkinson's Disease from Normal Controls Using Gray Matter in the Cerebellum".CEREBELLUM 16..1(2017):151-157
