CXCR4 expression varies significantly among different subtypes of glioblastoma multiforme (GBM) and its low expression or hypermethylation might predict favorable overall survival
机构：[a]Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, China[b]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经外科首都医科大学宣武医院[c]Department of Neurosurgery, Beijing Tongzhou District Chinese Medicine Hospital, Beijing, China
Background: CXCR4 is an oncogene in glioblastoma multiforme (GBM) but the mechanism of its dysregulation and its prognostic value in GBM have not been fully understood. Research design and methods: Bioinformatic analysis was performed by using R2 and the UCSC Xena browser based on data from GSE16011 in GEO datasets and in GBM cohort in TCGA database (TCGAGBM). Kaplan Meier curves of overall survival (OS) were generated to assess the association between CXCR4 expression/methylation and OS in patients with GBM. Results: GBM patients with high CXCR4 expression had significantly worse 5 and 10 yrs OS (p < 0.05). Across different GBM subtypes, there was an inverse relationship between overall DNA methylation and CXCR4 expression. CXCR4 expression was significantly lower in CpG island methylation phenotype (CIMP) group than in non CIMP group. Log rank test results showed that patients with high CXCR4 methylation (first tertile) had significantly better 5 yrs OS (p = 0.038). Conclusion: CXCR4 expression is regulated by DNA methylation in GBM and its low expression or hypermethylation might indicate favorable OS in GBM patients.
基金：
2015 MOHRSS: Funding Scheme to Outstanding Scientific and Technological Programs by Chinese Students Abroad (Grant No. 008-0064)
Foundational-clinical Research Project of Capital Medical University (Grant No. 303-01-007-0132).
第一作者机构：[a]Department of Neurosurgery, Yuquan Hospital, Tsinghua University, Beijing, China[*1]Department of Neurosurgery, Yuquan Hospital, Tsinghua University, No. 5 Shijingshan Road, Shijingshan District, Beijing 100040, China
通讯作者：
通讯机构：[*1]Department of Neurosurgery, Yuquan Hospital, Tsinghua University, No. 5 Shijingshan Road, Shijingshan District, Beijing 100040, China
推荐引用方式(GB/T 7714)：
Xinlong Ma,Feng Shang,Weidong Zhu,et al.CXCR4 expression varies significantly among different subtypes of glioblastoma multiforme (GBM) and its low expression or hypermethylation might predict favorable overall survival[J].EXPERT REVIEW OF NEUROTHERAPEUTICS.2017,17(9):941-946.doi:10.1080/14737175.2017.1351299.
APA：
Xinlong Ma,Feng Shang,Weidong Zhu&Qingtang Lin.(2017).CXCR4 expression varies significantly among different subtypes of glioblastoma multiforme (GBM) and its low expression or hypermethylation might predict favorable overall survival.EXPERT REVIEW OF NEUROTHERAPEUTICS,17,(9)
MLA：
Xinlong Ma,et al."CXCR4 expression varies significantly among different subtypes of glioblastoma multiforme (GBM) and its low expression or hypermethylation might predict favorable overall survival".EXPERT REVIEW OF NEUROTHERAPEUTICS 17..9(2017):941-946
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