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Dexmedetomidine inhibits lipopolysaccharide-induced inflammatory response in hippocampal astrocytes in vitro

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收录情况： ◇ SCIE

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机构： [1]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China [2]Department of Anatomy, Capital Medical University, 100069, Beijing, China

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关键词： Dexmedetomidine astrocytes NF-kappa B lipopolysaccharide

摘要：

Neuroinflammation mediated by astrocytes has been implicated in neurodegenerative diseases. Meanwhile, dexmedetomidine (DEX) has potent anti-inflammatory properties. The present study aimed to assess the effects of DEX on proinflammatory mediator production and release in astrocytes after lipopolysaccharide (LPS) induction. Cultured astrocytes, derived from hippocampi of 4-day-old rats, were treated with DEX at 0.1, 1, 10, and 100 mu M, respectively, in the presence or absence of LPS (1 mu g/ml). Then, mRNA and protein levels of the proinflammatory cytokines TNF-alpha, IL-6 and IL-1 beta were measured. The protein levels of I kappa B-alpha were also assessed. DEX at 0.1 mu M or 1 mu M did not affect the production of proinflammatory mediators. However, higher DEX levels (10 and 100 mu M) significantly decreased the amounts of TNF-alpha, IL-6, and IL-1 beta, both at the mRNA and protein levels, and increased the protein levels of I kappa B-alpha. These findings indicate that DEX inhibits neuroinflammation by interfering with NF-kappa B signaling, and may constitute a potential therapeutic agent for protecting patients from neuroinflammation associated diseases.

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出版当年[2016]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

最新[2025]版：

大类 | 4 区医学

小类 | 4 区医学：研究与实验

JCR分区：

出版当年[2015]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL

最新[2023]版：

Q4 MEDICINE, RESEARCH & EXPERIMENTAL

影响因子： 0.2 最新[2023版] 0.2 最新五年平均 1.075 出版当年[2015版] 1.15 出版当年五年平均 1.277 出版前一年[2014版] 1.069 出版后一年[2016版]

第一作者：

第一作者机构： [1]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China

通讯作者：

通讯机构： [1]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, 100053, Beijing, China

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