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Pyrrolidine Dithiocarbamate Prevents Neuroinflammation and Cognitive Dysfunction after Endotoxemia in Rats

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机构： [1]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China, [2]Department of Anatomy, Capital Medical University, Beijing, China, [3]Department of Medicine, Division of Nephrology, Durham VA and Duke University Medical Centers, Durham, NC, USA, [4]Department of Anesthesiology, Basic Science Division, Duke University Medical Center, Durham, NC, USA

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关键词： ageing astrocytes IL-1 beta lipopolysaccharide NF-kappa B PSD-95

摘要：

Systemic inflammation, for example as a result of infection, often contributes to long-term complications. Neuroinflammation and cognitive decline are key hallmarks of several neurological conditions, including advance age. The contribution of systemic inflammation to the central nervous system (CNS) remains not fully understood. Using a model of peripheral endotoxemia with lipopolysaccharide (LPS) we investigated the role of nuclear factor-kappa B (NF-kappa B) activity in mediating long-term neuroinflammation and cognitive dysfunction in aged rats. Herein we describe the anti-inflammatory effects of pyrrolidine dithiocarbamate (PDTC), a selective NF-kB inhibitor, in modulating systemic cytokines including tumor necrosis factor (TNF)-alpha and interleukin-1 beta) (IL-1 beta) and CNS markers after LPS exposure in aged rats. In the hippocampus, PDTC not only reduced neuroinflammation by modulating canonical NF-kappa B activity but also affected IL-1 beta expression in astrocytes. Parallel effects were observed on behavior and postsynaptic density-95 (PSD95), a marker of synaptic function. Taken together these changes improved acute and long-term cognitive function in aged rats after LPS exposure.

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出版当年[2015]版：

大类 | 2 区医学

小类 | 2 区老年医学 3 区神经科学

最新[2025]版：

大类 | 3 区医学

小类 | 3 区老年医学 3 区神经科学

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出版当年[2014]版：

Q1 GERIATRICS & GERONTOLOGY Q2 NEUROSCIENCES

最新[2023]版：

Q2 GERIATRICS & GERONTOLOGY Q2 NEUROSCIENCES

影响因子： 4.1 最新[2023版] 4.6 最新五年平均 4 出版当年[2014版] 4.725 出版当年五年平均 2.843 出版前一年[2013版] 4.348 出版后一年[2015版]

第一作者：

第一作者机构： [1]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China, [2]Department of Anatomy, Capital Medical University, Beijing, China,

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通讯机构： [1]Department of Anesthesiology, Xuanwu Hospital, Capital Medical University, Beijing, China,

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