机构:[1]Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China神经内科老年医学科首都医科大学宣武医院[2]Parkinson Disease Center of Beijing Institute of Brain Disorders, Beijing 100053, China[3]Beijing Key Laboratory on Parkinson’s Disease, Beijing 100053, China
Olfactory dysfunction has been reported in Parkinson's disease (PD) patients carrying the LRRK2 G2019S variant in Caucasians but rarely in those with the LRRK2 G2385R variant. In this study, we performed genotyping for the LRRK2 G2385R variant in PD patients recruited from the Movement Disorder Clinic of Xuanwu Hospital in Beijing and in healthy controls randomly selected from the Beijing Longitudinal Study on Aging cohort. The "five-odor olfactory detection array", an olfactory threshold test, was used to assess olfactory function. One hundred and eighty-six participants were enrolled, comprising 43 PD patients without (iPD) and 25 with (LRRK2-PD) the LRRK2 G2385R variant, and 118 healthy controls. Our results showed that the threshold of olfactory identification was significantly worse in PD patients than in controls, but not significantly different between the iPD and LRRK2-PD groups. These findings suggested that although olfactory function in LRRK2-PD patients is impaired, it is similar to that in iPD patients.
基金:
the Scientific Project of Ministry of Science and Technology of China(2012AA02A514),
the National Basic Research Development Program of China (2011CB504101),
the Beijing High Standard Health Human Resource Cultural Program in Health System, China (2009e1e12).
第一作者机构:[1]Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
通讯作者:
通讯机构:[1]Department of Neurobiology, Neurology and Geriatrics, Xuanwu Hospital of Capital Medical University, Beijing 100053, China[2]Parkinson Disease Center of Beijing Institute of Brain Disorders, Beijing 100053, China[3]Beijing Key Laboratory on Parkinson’s Disease, Beijing 100053, China
推荐引用方式(GB/T 7714):
Ming Cao,Zhu-Qin Gu,Yuan Li,et al.Olfactory Dysfunction in Parkinson's Disease Patients with the LRRK2 G2385R Variant[J].NEUROSCIENCE BULLETIN.2016,32(6):572-576.doi:10.1007/s12264-016-0070-5.
APA:
Ming Cao,Zhu-Qin Gu,Yuan Li,Hui Zhang,Xiao-Juan Dan...&Piu Chan.(2016).Olfactory Dysfunction in Parkinson's Disease Patients with the LRRK2 G2385R Variant.NEUROSCIENCE BULLETIN,32,(6)
MLA:
Ming Cao,et al."Olfactory Dysfunction in Parkinson's Disease Patients with the LRRK2 G2385R Variant".NEUROSCIENCE BULLETIN 32..6(2016):572-576