机构：[1]Department of Neurosurgery and Interventional Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China神经外科放射科首都医科大学宣武医院[2]Department of Neurological Surgery, Wayne State University School of Medicine, Detroit, MI[3]Department of Neurology, David Geffen School of Medicine, University of California Los Angeles Stroke Center[4]Department of Neurology, Academic Medical Center, University of Amsterdam, The Netherlands
Background and Purpose-We conducted a pilot feasibility and safety study of selective brain cooling with intra-arterial infusion of cold saline combined with endovascular reperfusion for acute ischemic stroke. Methods-Patients with large-vessel occlusion within 8 hours after symptom onset were enrolled. All patients received intra-arterial recanalization combined with infusion of cold isotonic saline (4 degrees C) in the ischemic territory through the angiographic catheter. Results-Twenty-six patients underwent the procedure, which was technically successful in all. The temperature of ischemic cerebral tissue was decreased by at least 2 degrees C during infusion of the cold solution, and systemic temperature was mildly reduced (maximum 0.3 degrees C). No obvious complications related to intra-arterial hypothermia were observed. Conclusions-Selective brain cooling by intra-arterial infusion of cold saline combined with endovascular recanalization therapy in acute ischemic stroke seems feasible and safe.
基金：
the National Science and Technology Supporting Plan (2011BAI08B07)
Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZY201309).
第一作者机构：[1]Department of Neurosurgery and Interventional Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[*1]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, 45 Chang Chun St, Beijing, 100053, China
推荐引用方式(GB/T 7714)：
Jian Chen ,Liqiang Liu ,Hongqi Zhang ,et al.Endovascular Hypothermia in Acute Ischemic Stroke Pilot Study of Selective Intra-Arterial Cold Saline Infusion[J].STROKE.2016,47(7):1933-1935.doi:10.1161/STROKEAHA.116.012727.
APA：
Jian Chen,,Liqiang Liu,,Hongqi Zhang,,Xiaokun Geng,,Liqun Jiao,...&Xunming Ji,.(2016).Endovascular Hypothermia in Acute Ischemic Stroke Pilot Study of Selective Intra-Arterial Cold Saline Infusion.STROKE,47,(7)
MLA：
Jian Chen,,et al."Endovascular Hypothermia in Acute Ischemic Stroke Pilot Study of Selective Intra-Arterial Cold Saline Infusion".STROKE 47..7(2016):1933-1935
医学