机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[2]Department of Geriatrics, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[3]Core Laboratory for Clinical Medical Research, Beijing Tiantan Hospital, Capital Medical University, Beijing, China[4]Department of Physiology, Capital Medical University, Beijing, China[5]Department of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China[6]Department of Neurology, Beijing Xuanwu Hospital, Capital Medical University, Beijing, China神经内科首都医科大学宣武医院[7]China National Clinical Research Center for Neurological Diseases, Beijing, China[8]Center of Parkinson’s Disease, Beijing Institute for Brain Disorders, Beijing, China[9]Beijing Key Laboratory on Parkinson’s Disease, Beijing, China
Objectives: To investigate the demographic features, clinical features, and potential mechanism in patients with Parkinson disease (PD) with pure apathy. Method: A total of 145 patients with PD without depression and dementia and 30 age-matched controls were consecutively recruited. Patients with PD were evaluated by Apathy Scale (AS), scales for motor symptoms and quality of life. The levels of iron, oxidative and neuroinflammatory factors, -synuclein oligomer, and dopamine in cerebrospinal fluid (CSF) from patients with PD and controls were detected by enzyme-linked immunosorbent assay, chemical colorimetric method, and high-performance liquid chromatography. Comparisons between PD with pure apathy and with no pure apathy groups and correlation between AS score and the levels of above factors were analyzed. Results: There were 64 (44.14%) cases in PD-apathy group. The PD-apathy group had older age, (97.81 10.82) years versus (61.86 +/- 10.80) years, and severer quality of life (P < .05). The PD-apathy and PD without apathy groups presented no remarkable differences in motor symptoms (P > .05). The levels of iron, hydroxyl radical (<bold>OH</bold>), hydrogen peroxide (H2O2), and -synuclein oligomer in CSF in PD-apathy group were significantly higher than that in PD without the apathy group (P < .05). In patients with PD, the AS score was positively correlated with the levels of iron, <bold>OH</bold>, H2O2 and -synuclein oligomer in CSF (r = 19.838, .063, 1.046, and 0.498, respectively, P < .05). In PD-apathy group, iron level was positively correlated with <bold>OH level </bold>(r = .011, P < .05), and H2O2 level was positively correlated with -synuclein oligomer level in CSF (r = .045, P < .05). Conclusion: Patients with PD had high prevalence of pure apathy. Patients with PD having pure apathy had older age. Pure apathy reduced quality of life for patients without worsening motor function. Excessive iron and -synuclein oligomer in brain commonly contributed to pure apathy of PD through potential mechanism of oxidative stress.
基金：
the National Key Basic Research Program of China (2011CB504100);
the National Natural Science Foundation of China (81571229, 81071015, 30770745),
the Natural Science Foundation of Beijing, China (7082032),
National Key Technology Research and Development Program of the Ministry of Science and Technology of China (2013BAI09B03),
The project of Beijing Institute for Brain Disorders(BIBD-PXM2013_014226_07_000084),
High Level Technical Personnel Training Project of Beijing Health System, China (2009-3-26),
The Project of Construction of Innovative Teams and Teacher Career Development for Universities and Colleges Under Beijing Municipality (IDHT20140514),
Capital Clinical Characteristic Application Research (Z121107001012161),
the Beijing Healthcare Research Project, China (JING-15-2, JING-15-3),
Excellent Personnel Training Project of Beijing, China (20071D0300400076),
Important National Science & Technology Specific Projects (2011ZX09102-003-01),
Key Project of National Natural Science Foundation of China (81030062),
Key Project of Beijing Natural Science Foundation (kz200910025001)
Basic-Clinical Research Cooperation Funding of Capital Medical University (10JL49, 14JL15, 2015-JL-PT-X04),
Youth Research Fund, Beijing Tiantan Hospital, Capital Medical University, China (2014-YQN-YS-18,2015-YQN-05, 2015-YQN-14, 2015-YQN-15, 2015-YQN-17).
第一作者机构：[1]Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[*1]Beijing Tiantan Hospital, Capital Medical University, Beijing, 100050, China.
推荐引用方式(GB/T 7714)：
Fang Wang,Shu-Yang Yu ,Li-Jun Zuo ,et al.Excessive Iron and -Synuclein Oligomer in Brain are Relevant to Pure Apathy in Parkinson Disease[J].JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY.2016,29(4):187-194.doi:10.1177/0891988716632918.
APA：
Fang Wang,Shu-Yang Yu,,Li-Jun Zuo,,Chen-Jie Cao,,Yang Hu,...&Wei Zhang,.(2016).Excessive Iron and -Synuclein Oligomer in Brain are Relevant to Pure Apathy in Parkinson Disease.JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY,29,(4)
MLA：
Fang Wang,et al."Excessive Iron and -Synuclein Oligomer in Brain are Relevant to Pure Apathy in Parkinson Disease".JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY 29..4(2016):187-194
