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miR-137 suppresses tumor growth of malignant melanoma by targeting aurora kinase A

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收录情况： ◇ SCIE

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机构： [a]Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053, China [b]Department of Dermatology and Venereal Disease, Capital Medical University, Beijing 100069, China

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关键词： miR-137 Malignant melanoma Aurora kinase A Cell growth

摘要：

As an oncogene, aurora kinase A (AURKA) is overexpressed in various types of human cancers. However, the expression and roles of AURKA in malignant melanoma are largely unknown. In this study, a miR-137-AURKA axis was revealed to regulate melanoma growth. We found a significant increase in levels of AURKA in melanoma. Both genetic knockdown and pharmacologic inhibition of AURKA decreased tumor cell growth in vitro and in vivo. Further found that miR-137 reduced AURKA expression through interaction with its 3' untranslated region (3'UTR) and that miR-137 was negatively correlated with AURKA expression in melanoma specimens. Overexpression of miR-137 decreased cell proliferation and colony formation in vitro. Notably, re-expression of AURKA significantly rescued miR-137-mediated suppression of cell growth and clonality. In summary, these results reveal that miR-137 functions as a tumor suppressor by targeting AURKA, providing new insights into investigation of therapeutic strategies against malignant melanoma. (C) 2016 Elsevier Inc. All rights reserved.

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出版当年[2015]版：

大类 | 3 区生物

小类 | 4 区生化与分子生物学 4 区生物物理

最新[2023]版：

大类 | 3 区生物学

小类 | 3 区生物物理 4 区生化与分子生物学

JCR分区：

出版当年[2014]版：

Q3 BIOPHYSICS Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

最新[2023]版：

Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Q3 BIOPHYSICS

影响因子： 2.5 最新[2023版] 2.7 最新五年平均 2.297 出版当年[2014版] 2.382 出版当年五年平均 2.281 出版前一年[2013版] 2.371 出版后一年[2015版]

第一作者：

第一作者机构： [a]Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, Beijing 100053, China

通讯作者：

通讯机构： [*1]Department of Dermatology and Venereal Disease, Xuanwu Hospital, Capital Medical University, 45 Changchun Street, Western District, Beijing 100053, China

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