机构：[a]State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China[b]Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China[c]Faculty of Psychology, Southwest University (SWU), Chongqing 400715, China[d]School of Psychology, Beijing Normal University, Beijing, China[e]Xuan Wu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院
Previous studies using resting-state functional magnetic resonance imaging (fMRI) have found abnormal spontaneous neural activity in patients with major depressive disorder (MDD). Yet, the frequency dependent neural activity in MDD is largely unknown. Here, we used resting-state fMRI and regional homogeneity (ReHo) methods to investigate spontaneous neural activity in specific frequency bands of 31 MDD patients and 31 age-, gender- and education-matched healthy controls. We examined spontaneous neural activity in three frequency bands: slow-4 (0.027-0.073 Hz), slow-5 (0.010-0.027 Hz), and the typical band (0.01-0.08 Hz). Compared to controls, MDD patients showed increased ReHo in the middle frontal gyrus (MFG) and decreased ReHo in the fusiform and postcentral gyrus at the typical band. Importantly, MDD patients showed increased ReHo in the middle occipital gyrus (MOG) and decreased ReHo in the anterior cingulate cortex (ACC), inferior frontal gyrus (IFG), superior frontal gyrus (SFG) and the bilateral thalamus in the slow-4 band, while they showed increased ReHo in the medial prefrontal cortex (mPFC) in the slow-5 band. Our results suggest that the abnormality of ReHo in MDD is associated with the frequency band and that future studies should take frequency band effect into account when examining spontaneous neural activity. (C) 2016 Elsevier B.V. All rights reserved.
基金：
the National Natural Science Foun-dation of China (31070900; 31271087),
the Program for NewCentury Excellent Talents in University (2011) by the Ministryof Education
the Fundamental Research Funds for the Cen-tral Universities (SWU1209101),
the Open Research Fund ofthe State Key Laboratory of Cognitive Neuroscience and Learning(CNLYB1310).
第一作者机构：[a]State Key Laboratory of Cognitive Neuroscience and Learning & IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China[b]Key Laboratory of Cognition and Personality (SWU), Ministry of Education, Chongqing, China
通讯作者：
通讯机构：[*1]School of Psychology, Beijing Normal University, Bei-jing 100875, China.[*2]Faculty of Psychology, Southwest University, Beibei,Chongqing 400715, China.
推荐引用方式(GB/T 7714)：
Song Xue,Xu Wang,Wanqian Wang,et al.Frequency-dependent alterations in regional homogeneity in major depression[J].BEHAVIOURAL BRAIN RESEARCH.2016,306:13-19.doi:10.1016/j.bbr.2016.03.012.
APA：
Song Xue,Xu Wang,Wanqian Wang,Jia Liu&Jiang Qiu.(2016).Frequency-dependent alterations in regional homogeneity in major depression.BEHAVIOURAL BRAIN RESEARCH,306,
MLA：
Song Xue,et al."Frequency-dependent alterations in regional homogeneity in major depression".BEHAVIOURAL BRAIN RESEARCH 306.(2016):13-19
