机构：[1]Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China,[2]Brainnetome Center, Chinese Academy of Sciences, Beijing, China,[3]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China,[4]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China ,神经内科首都医科大学宣武医院[5]Department of Radiology, Xuanwu Hospital of Capital Medical University, Beijing, China,放射科首都医科大学宣武医院[6]Department of Radiology, Tianjin Medical University General Hospital, Tianjin, China,[7]The Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia,[8]CAS Center for Excellence in Brain Science, Institute of Automation, Chinese Academy of Sciences, Beijing, China
Alzheimers disease (AD) is a progressive neurodegenerative disorder which causes dementia, especially in the elderly. The posteromedial cortex (PMC), which consists of several subregions involved in distinct functions, is one of the critical regions associated with the progression and severity of AD. However, previous studies always ignored the heterogeneity of the PMC and focused on one stage of AD. Using resting-state functional magnetic resonance imaging, we studied the respective alterations of each subregion within the PMC along the progression of AD. Our data set consisted of 21 healthy controls, 18 patients with mild cognitive impairment (MCI), 17 patients with mild AD (mAD), and 18 patients with severe AD (sAD). We investigated the functional alterations of each subregion within the PMC in different stages of AD. We found that subregions within the PMC have differential vulnerability in AD. Disruptions in functional connectivity began in the transition area between the precuneus and the posterior cingulate cortex (PCC) and then extended to other subregions of the PMC. In addition, each of these subregions was associated with distinct alterations in the functional networks that we were able to relate to AD. Our research demonstrated functional changes within the PMC in the progression of AD and may elucidate potential biomarkers for clinical applications.
基金：
the Natural Science Foundation of China (Grants 91432302; 81471120, 81571062, 31500867),
the Youth Innovation Promotion Association CAS, Grant number 2014119;
the Natural Science Foundation of Beijing, Grant number 7152096;
the Beijing Nova Program, grant number Z1511000003150112.
第一作者机构：[1]Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China,
共同第一作者：
通讯作者：
通讯机构：[1]Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, China,[2]Brainnetome Center, Chinese Academy of Sciences, Beijing, China,[3]National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China,[7]The Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia,[8]CAS Center for Excellence in Brain Science, Institute of Automation, Chinese Academy of Sciences, Beijing, China
推荐引用方式(GB/T 7714)：
Yan Wu,Yaqin Zhang,Yong Liu,et al.Distinct Changes in Functional Connectivity in Posteromedial Cortex Subregions during the Progress of Alzheimer's Disease[J].FRONTIERS IN NEUROANATOMY.2016,10(APR):41.doi:10.3389/fnana.2016.00041.
APA：
Yan Wu,Yaqin Zhang,Yong Liu,Jieqiong Liu,Yunyun Duan...&Tianzi Jiang.(2016).Distinct Changes in Functional Connectivity in Posteromedial Cortex Subregions during the Progress of Alzheimer's Disease.FRONTIERS IN NEUROANATOMY,10,(APR)
MLA：
Yan Wu,et al."Distinct Changes in Functional Connectivity in Posteromedial Cortex Subregions during the Progress of Alzheimer's Disease".FRONTIERS IN NEUROANATOMY 10..APR(2016):41
