机构：[1]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, China神经内科首都医科大学宣武医院[2]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100053, China[3]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing 100053, China[4]Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing 100053, China
Genome-wide association studies (GWASs) have revealed a plethora of putative susceptibility genes for Alzheimer's disease (AD). With the sole exception of the APOE gene, these AD susceptibility genes have not been unequivocally validated in independent studies. No single novel functional risk genetic variant has been identified. In this review, we evaluate recent GWASs of AD, and discuss their significance, limitations, and challenges in the investigation of the genetic spectrum of AD.
基金：
CHINACANADA Joint Initiative on Alzheimer's Disease and Related Disorders (81261120571),
the National Basic Research Development Program (973 Program) of China (2011CB504104),
Scientific Promoting Project of Beijing Institute for Brain Disorders (BIBDPXM2014_014226_000016),
Seed Grant of International Alliance of Translational Neuroscience (PXM2014_014226_000006),
Key Medical Professional Development Plan of Beijing Municipal Administration of Hospitals (ZYLX201301),
the National Science and Technology Major Project for "Major New Drug Innovation and Development" of the Twelfth 5-year Plan Period of China(2011ZX09307-001-03),
the Major Project of the Science and Technology Plan of the Beijing Municipal Science & Technology Commission of China (D111107003111009),
the National Key Technology R&D Program in the Eleventh Five-year Plan Period of China (2006BAI02B01),
the Key Project of the National Natural Science Foundation of China (30830045).
第一作者机构：[1]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Neurology, Xuan Wu Hospital of the Capital Medical University, Beijing 100053, China[2]Center of Alzheimer’s Disease, Beijing Institute for Brain Disorders, Beijing 100053, China[3]Beijing Key Laboratory of Geriatric Cognitive Disorders, Beijing 100053, China[4]Neurodegenerative Laboratory of Ministry of Education of the People’s Republic of China, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Luxi Shen,Jianping Jia.An Overview of Genome-Wide Association Studies in Alzheimer's Disease[J].NEUROSCIENCE BULLETIN.2016,32(2):183-190.doi:10.1007/s12264-016-0011-3.
APA：
Luxi Shen&Jianping Jia.(2016).An Overview of Genome-Wide Association Studies in Alzheimer's Disease.NEUROSCIENCE BULLETIN,32,(2)
MLA：
Luxi Shen,et al."An Overview of Genome-Wide Association Studies in Alzheimer's Disease".NEUROSCIENCE BULLETIN 32..2(2016):183-190
