机构：[1]Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院循证医学中心[2]Department of Vascular Ultrasonography, Xuanwu Hospital, Capital Medical University, Beijing, China血管超声科首都医科大学宣武医院[3]Department of Neurological Surgery, Xuanwu Hospital, Capital Medical University, Beijing, China首都医科大学宣武医院
We investigated the association between kidney dysfunction and carotid atherosclerosis in community-based older adults. This study consisted of 1257 participants, aged 55 years and older and free of cardiovascular disease. Kidney dysfunction was classified as mild, moderate, and severe (estimated glomerular filtration rate, 45-59, 30-44, and <30 mL/min/1.73 m(2), respectively). We found that the mean common carotid artery intima-media thickness (CCA-IMT) progressively increased with decrement in kidney function (P < .001). Even mild kidney dysfunction was significantly associated with CCA-IMT thickening (CCA-IMT 1.0 mm; odds ratio [OR] 1.52; 95% confidence interval [CI] 1.16-1.99) compared to normal kidney function. A significantly increased presence of heterogeneous plaque was observed in relation to decreased kidney function (P for trend = .011), that is, even a mild kidney dysfunction was a potential independent risk factor for heterogeneous plaque (OR 1.43; 95% CI 1.04-1.98). Mild kidney dysfunction may be a predictor of early or accelerated carotid atherosclerosis in older adults.
基金：
the Commission of Science and Technology of Beijing (Grant No: D121100004912002),
Beijing Natural Science Foundation (Grant No: 7152068)
Xuanwu Hospital, Capital Medical University, Beijing, China.
第一作者机构：[1]Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, Beijing, China
通讯作者：
通讯机构：[*1]Evidence-Based Medical Center, Xuanwu Hospital, Capital Medical University, #45 Changchun Street, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Xiang Gu ,Xianghua Fang,Yang Hua,et al.Association Between Kidney Dysfunction and Carotid Atherosclerosis in Community-Based Older Adults in China[J].ANGIOLOGY.2016,67(3):252-258.doi:10.1177/0003319715586505.
APA：
Xiang Gu,,Xianghua Fang,Yang Hua,Zhe Tang,Xunming Ji...&Zhongying Zhang.(2016).Association Between Kidney Dysfunction and Carotid Atherosclerosis in Community-Based Older Adults in China.ANGIOLOGY,67,(3)
MLA：
Xiang Gu,,et al."Association Between Kidney Dysfunction and Carotid Atherosclerosis in Community-Based Older Adults in China".ANGIOLOGY 67..3(2016):252-258
