机构：[a]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University,[b]Department of Epidemiology, School of Public Health, Medical College of Soochow University,[c]Department of Neurology, The Suzhou Hospital of Traditional Chinese Medicine,[d]Institute of Neuroscience, Soochow University, Suzhou , China
Background: The effects of the estimated glomerular filtration rate (eGFR) and cystatin C on clinical outcomes on intracerebral hemorrhage (ICH) remain unclear. We investigated the associations of eGFR and cystatin C with 3-month functional outcome and all-cause mortality in acute ICH patients. Methods: A total of 365 patients with acute ICH were enrolled. Serum creatinine and cystatin C levels were measured within 24 h of admission. Outcomes at 3-month were evaluated by interviews with patients or their family members. Poor functional outcome was defined as a modified Rankin Scale score >= 3. Results: During the 3-month follow-up, 154 patients experienced poor functional outcome, and 48 patients died from all causes. Low eGFR level was associated with poor outcome (adjusted OR 8.95; 95% CI 2.13-37.66; p-trend = 0.045) and all-cause mortality (adjusted hazards ratio (HR) 5.10; 95% CI 2.00-13.03; p-trend = 0.001). Additionally, a high cystatin C level was also found to be associated with all-cause mortality (adjusted HR 4.01; 95% CI 1.09-14.72; p-trend = 0.015). However, no significant association between cystatin C and poor functional outcome was observed (p-trend = 0.615). Conclusions: Low eGFR at baseline predicts poor functional outcome and all-cause mortality at 3-month in acute ICH patients. Also, high cystatin C was associated with increased risk of mortality but not with poor functional outcome. (C) 2016 S. Karger AG, Basel
基金：
This work was supported in part by grants from the National
Natural Science Foundation of China (81471195), Suzhou Clinical
Research Center of Neurological Disease (Szzx201503), the Second
Affiliated Hospital of Soochow University Preponderant Clinic
Discipline Group Project Funding (XKQ2015002). It was also
partly supported by the Priority Academic Program Development
of Jiangsu Higher Education Institutions (PAPD).
第一作者机构：[a]Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University,
通讯作者：
通讯机构：[*1]Department of Neurology Second Affiliated Hospital of Soochow University No. 1055, Sanxiang Road, Suzhou, Jiangsu 215004 (China)
推荐引用方式(GB/T 7714)：
Shoujiang You,Luyao Shi,Chongke Zhong,et al.Prognostic Significance of Estimated Glomerular Filtration Rate and Cystatin C in Patients with Acute Intracerebral Hemorrhage[J].CEREBROVASCULAR DISEASES.2016,42(5-6):455-463.doi:10.1159/000448340.
APA：
Shoujiang You,Luyao Shi,Chongke Zhong,Jiaping Xu,Qiao Han...&Chunfeng Liu.(2016).Prognostic Significance of Estimated Glomerular Filtration Rate and Cystatin C in Patients with Acute Intracerebral Hemorrhage.CEREBROVASCULAR DISEASES,42,(5-6)
MLA：
Shoujiang You,et al."Prognostic Significance of Estimated Glomerular Filtration Rate and Cystatin C in Patients with Acute Intracerebral Hemorrhage".CEREBROVASCULAR DISEASES 42..5-6(2016):455-463
