机构：[a]Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University,Beijing , China神经内科首都医科大学宣武医院[b]Beijing Institute of Geriatrics,Beijing , China[c]Key Laboratory on Neurodegenerative Disease of Ministry of Education and Key Laboratory on Parkinson’s Disease of Beijing,Beijing , China[d]Center of Parkinson’s Disease, Beijing Institutes of Brain Disorders, Beijing , China
Aims: To confirm whether the presence and/or timing of rapid eye movement sleep behavior disorder (RBD) onset were associated with differences in clinical features of Parkinson's disease (PD), clinical characteristics of PD patients with RBD occurring before and after PD diagnosis were investigated. Methods: Consecutive PD patients were enrolled between July 2011 and February 2012. RBD questionnaire Hong Kong and clinical interviews were used to identify RBD symptoms and onsets. All patients underwent evaluations to collect clinical and treatment information. Results: Of all 79 PD patients, 21 (26.6%) and 22 (27.8%) patients had RBD prior to (RBD-PD) and after PD diagnosis (PD-RBD), respectively. Thirty-six (45.6%) PD patients reported no RBD at the time of study (PD-NRBD). PD-RBD had similar clinical features as PD-NRBD did except that Epworth sleepiness scale score was significantly higher in PD-RBD (p = 0.04). Compared to PD-RBD and PD-NRBD, RBD-PD had a higher frequency of reporting excessive daytime sleepiness (p = 0.019, p = 0.008, respectively) and constipation (p = 0.046, p = 0.032, respectively). Conclusion: Our preliminary results suggest that RBD-PD might be clinically different from PD-RBD, which appears to share similar characteristics with PD-NRBD, regarding only non -motor functions. (C) 2016 S. Karger AG, Basel
基金：
the Ministry of Science and Technology of China (2012AA02A514, 2011CB504101),
the Ministry of Health of China (201002011),
the Beijing High Standard Health Human Resource Cultural Program in Health System (2009-1-12).
第一作者机构：[a]Department of Neurology and Neurobiology, Xuanwu Hospital of Capital Medical University,Beijing , China[b]Beijing Institute of Geriatrics,Beijing , China
通讯作者：
通讯机构：[*1]Department of Neurobiology and Neurology Xuanwu Hospital of Capital Medical University #45 Changchun Street, Beijing 100053 (China)
推荐引用方式(GB/T 7714)：
Hui Zhang,Zhuqin Gu,Liang Sun,et al.Clinical Manifestation of Parkinson's Disease in Association with Rapid Eye Movement Sleep Behavior Disorder Onset[J].EUROPEAN NEUROLOGY.2016,76(3-4):154-160.doi:10.1159/000449374.
APA：
Hui Zhang,Zhuqin Gu,Liang Sun,Ming Cao,Dawei Li...&Piu Chan.(2016).Clinical Manifestation of Parkinson's Disease in Association with Rapid Eye Movement Sleep Behavior Disorder Onset.EUROPEAN NEUROLOGY,76,(3-4)
MLA：
Hui Zhang,et al."Clinical Manifestation of Parkinson's Disease in Association with Rapid Eye Movement Sleep Behavior Disorder Onset".EUROPEAN NEUROLOGY 76..3-4(2016):154-160
