机构:[1]Department of Neurology and Sleep Center, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[2]Institute of Neuroscience, Soochow University, Suzhou 215123, China
Rapid eye movement sleep behavior disorder (RBD) is one of the most common non-motor symptoms of parkinsonism, and it may serve as a prodromal marker of neurodegenerative disease. The mechanism underlying RBD is unclear. Several prospective studies have reported that specific non-motor symptoms predict a conversion risk of developing a neurodegenerative disease, including olfactory dysfunction, abnormal color vision, autonomic dysfunction, excessive daytime sleepiness, depression, and cognitive impairment. Parkinson's disease (PD) with RBD exhibits clinical heterogeneity with respect to motor and non-motor symptoms compared with PD without RBD. In this review, we describe the main clinical and pathogenic features of RBD, focusing on its association with other non-motor symptoms of parkinsonism.
基金:
This review was supported by the National
Natural Science Foundation of China (91649114), the Jiangsu
Provincial Special Program of Medical Science, China
(BL2014042), a Jiangsu Provincial Medical Key Discipline Project,
the Suzhou Clinical Research Center of Neurological Disease
(Szzx201503), Jiangsu Province Ordinary University Professional
Degree Graduate Practice Innovation, China (SJZZ16-0242), and the
Priority Academic Program Development of Jiangsu Higher Education
Institutions, China.
第一作者机构:[1]Department of Neurology and Sleep Center, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China
共同第一作者:
通讯作者:
通讯机构:[1]Department of Neurology and Sleep Center, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China[2]Institute of Neuroscience, Soochow University, Suzhou 215123, China
推荐引用方式(GB/T 7714):
Jin Hong,Zhang Jin-Ru,Shen Yun,et al.Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism[J].NEUROSCIENCE BULLETIN.2017,33(5):576-584.doi:10.1007/s12264-017-0164-8.
APA:
Jin, Hong,Zhang, Jin-Ru,Shen, Yun&Liu, Chun-Feng.(2017).Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism.NEUROSCIENCE BULLETIN,33,(5)
MLA:
Jin, Hong,et al."Clinical Significance of REM Sleep Behavior Disorders and Other Non-motor Symptoms of Parkinsonism".NEUROSCIENCE BULLETIN 33..5(2017):576-584