机构：[a]Departments of Neurology,Xuanwu Hospital of Capital Medical University, Beijing神经内科首都医科大学宣武医院[b]Departments of Neurosurgery,Xuanwu Hospital of Capital Medical University, Beijing神经外科首都医科大学宣武医院[c]Department of Anesthesiology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai , China
Background: Remote ischemic preconditioning (RIPC) of the limb has been shown to induce ischemic tolerance in basic and clinical studies that focused on sustained large artery occlusion rather than small vessel disease (SVD). This study aimed to evaluate the protective effects of brief repetitive limb RIPC on patients with cerebral SVD. Methods: Seventeen patients with cerebral SVD were enrolled. Patients underwent 5 ischemia-reperfusion cycles of preconditioning/sham preconditioning on both upper limbs twice a day for 1 year. Cerebral hemodynamic indexes, brain lesions, cognitive functions and assessment outcomes of dizziness handicap inventory (DHI) were analyzed. Results: In the RIPC group, the mean flow velocity (MFV) of the left middle cerebral artery (MCA) was accelerated (57.33 (52.3361.34) vs. 51.33 (48.83-58.33), respectively; p = 0.038), and the post-treatment DHI score was reduced (18 (13-19) vs. 34 (21-45), respectively; p = 0.043). The post-treatment volume of the white matter lesions (WMLs) was also reduced (4.19 (2.96-7.25) vs. 6.06 (4.67-10.95), respectively; p = 0.050). There was no remarkable difference between the 2 groups either before or after treatment. Conclusion: The present study indicates that RIPC has potential beneficial effects on cerebral SVD by increasing the MFV of MCA, decreasing the DHI score as well as the volume of WMLs in patients with SVD. (C) 2016 S. Karger AG, Basel
基金：
the Talent Cultivation Foundation, the High-Level Health Technology Talent Construction Program of the Beijing Municipal Health Bureau (008-0019);
the Talent Cultivation Foundation, Beijing Outstanding Talents Cultivation Fund, Beijing Municipal Committee (2012D005018000007);
the Natural Science Foundation, Shanghai Jiao Tong University School of Medicine (YZ1006).
第一作者机构：[a]Departments of Neurology,Xuanwu Hospital of Capital Medical University, Beijing
通讯作者：
通讯机构：[*1]Department of Neurology, Xuanwu Hospital of Capital Medical University, 45 Changchun Street, Xicheng District, Beijing 100053 (China)[*2]Department of Anesthesiology, Ruijin Hospital Shanghai Jiao Tong University School of Medicine, 197 Ruijin Road, Luwan District, Shanghai 200025 (China)
推荐引用方式(GB/T 7714)：
Taomian Mi,Fei Yu,Xunming Ji,et al.The Interventional Effect of Remote Ischemic Preconditioning on Cerebral Small Vessel Disease: A Pilot Randomized Clinical Trial[J].EUROPEAN NEUROLOGY.2016,76(1-2):28-34.doi:10.1159/000447536.
APA：
Taomian Mi,Fei Yu,Xunming Ji,Yongxin Sun&Dongmei Qu.(2016).The Interventional Effect of Remote Ischemic Preconditioning on Cerebral Small Vessel Disease: A Pilot Randomized Clinical Trial.EUROPEAN NEUROLOGY,76,(1-2)
MLA：
Taomian Mi,et al."The Interventional Effect of Remote Ischemic Preconditioning on Cerebral Small Vessel Disease: A Pilot Randomized Clinical Trial".EUROPEAN NEUROLOGY 76..1-2(2016):28-34
