机构：[1]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing 100053, P. R. China首都医科大学宣武医院[2]Beijing Engineering Research Center for Nerve System Drugs, Beijing 100053, P. R. China[3]Beijing Institute for Brain Disorders, Beijing 100053, P. R. China[4]Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, P. R. China
Alzheimer's disease (AD) is a multifactorial complex disease. The pathogenesis of AD is very complicated, and involves the beta-amyloid (A beta) cascade, tau hyperphosphorylation, neuroinflammation, oxidative stress, mitochondrial dysfunction, reduced levels of neurotrophic factors, and damage and loss of synapses as well as cholinergic neurons. The multi-target characteristics of traditional Chinese medicine (TCM) may be advantageous over single-target drugs in the treatment of complex diseases. These drugs have therefore attracted more attention in the research and development of AD therapies. This review describes advances made in experimental studies of TCM for AD treatment. It discusses research, from our group and other laboratories, on TCM compound drugs (Shenwu capsule) and approximately 10 Chinese medicinal herb extracts (tetrahydroxystilbene glucoside, epimedium flavonoid, icariin, cornel iridoid glycoside, ginsenoside, puerarin, clausenamide, huperzine A, and timosaponins).
基金：
National Science and Technology Major Project of China [2015ZX09101-016]; National Natural Science Foundation of China [81273498, 81473373]; Beijing Natural Science Foundation [7132110]
第一作者机构：[1]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing 100053, P. R. China[2]Beijing Engineering Research Center for Nerve System Drugs, Beijing 100053, P. R. China[3]Beijing Institute for Brain Disorders, Beijing 100053, P. R. China[4]Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing 100053, P. R. China[*1]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, 45 Chang-chun Street, Beijing 100053, P. R. China
通讯作者：
通讯机构：[*1]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, 45 Chang-chun Street, Beijing 100053, P. R. China
推荐引用方式(GB/T 7714)：
Li Lin,Zhang Lan,Yang Cui-cui.Multi-Target Strategy and Experimental Studies of Traditional Chinese Medicine for Alzheimer's Disease Therapy[J].CURRENT TOPICS IN MEDICINAL CHEMISTRY.2016,16(5):537-548.doi:10.2174/1568026615666150813144003.
APA：
Li, Lin,Zhang, Lan&Yang, Cui-cui.(2016).Multi-Target Strategy and Experimental Studies of Traditional Chinese Medicine for Alzheimer's Disease Therapy.CURRENT TOPICS IN MEDICINAL CHEMISTRY,16,(5)
MLA：
Li, Lin,et al."Multi-Target Strategy and Experimental Studies of Traditional Chinese Medicine for Alzheimer's Disease Therapy".CURRENT TOPICS IN MEDICINAL CHEMISTRY 16..5(2016):537-548
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