Goal-directed Fluid Therapy May Improve Hemodynamic Stability of Parturient with Hypertensive Disorders of Pregnancy Under Combined Spinal Epidural Anesthesia for Cesarean Delivery and the Well-being of Newborns
机构：[1]Department of Anesthesiology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China麻醉手术科首都医科大学宣武医院[2]Department of Obstetrics and Gynecology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China妇产科首都医科大学宣武医院[3]Department of Surgery and Cancer, Pain Medicine and Intensive Care, Faculty of Medicine, Chelsea and Westminster Hospital, Imperial College, London, United Kingdom
Background: Hypotension induced by combined spinal epidural anesthesia in parturient with hypertensive disorders of pregnancy (HDP) can easily compromise blood supply to vital organs including uteroplacental perfusion and result in fetal distress. The aim of this study was to investigate whether the goal-directed fluid therapy (GDFT) with LiDCOrapid system can improve well-being of both HDP parturient and their babies. Methods: Fifty-two stable HDP parturient scheduled for elective cesarean delivery were recruited. After loading with 10 ml/kg lactated Ringers solution (LR), parturient were randomized to the GDFT and control group. In the GDFT group, individualized fluid therapy was guided by increase in stroke volume (Delta SV) provided via LiDCOrapid system. The control group received the routine fluid therapy. The primary endpoints included maternal hypotension and the doses of vasopressors administered prior to fetal delivery. The secondary endpoints included umbilical blood gas abnormalities and neonatal adverse events. Results: The severity of HDP was similar between two groups. The total LR infusion (P < 0.01) and urine output (P < 0.05) were higher in the GDFT group than in the control group. Following twice fluid challenge tests, the systolic blood pressure, mean blood pressure, cardiac output and SV in the GDFT group were significantly higher, and the heart rate was lower than in the control group. The incidence of maternal hypotension and doses of phenylephrine used prior to fetal delivery were significantly higher in the control group than in the GDFT group (P < 0.01). There were no differences in the Apgar scores between two groups. In the control group, the mean values of pH in umbilical artery/vein were remarkably decreased (P < 0.05), and the incidences of neonatal hypercapnia and hypoxemia were statistically increased (P < 0.05) than in the GDFT group. Conclusions: Dynamic responsiveness guided fluid therapy with the LiDCOrapid system may provide potential benefits to stable HDP parturient and their babies.
第一作者机构：[1]Department of Anesthesiology, Xuan Wu Hospital, Capital Medical University, Beijing 100053, China
通讯作者：
通讯机构：[*1]Department of Anesthesiology, Xuan Wu Hospital, Capital Medical University, No. 45 Chang Chun Street, Xicheng District, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Wei Xiao,Qing-Fang Duan,Wen-Ya Fu,et al.Goal-directed Fluid Therapy May Improve Hemodynamic Stability of Parturient with Hypertensive Disorders of Pregnancy Under Combined Spinal Epidural Anesthesia for Cesarean Delivery and the Well-being of Newborns[J].CHINESE MEDICAL JOURNAL.2015,128(14):1922-1931.doi:10.4103/0366-6999.160546.
APA：
Wei Xiao,Qing-Fang Duan,Wen-Ya Fu,Xin-Zuo Chi,Feng-Ying Wang...&Lei Zhao.(2015).Goal-directed Fluid Therapy May Improve Hemodynamic Stability of Parturient with Hypertensive Disorders of Pregnancy Under Combined Spinal Epidural Anesthesia for Cesarean Delivery and the Well-being of Newborns.CHINESE MEDICAL JOURNAL,128,(14)
MLA：
Wei Xiao,et al."Goal-directed Fluid Therapy May Improve Hemodynamic Stability of Parturient with Hypertensive Disorders of Pregnancy Under Combined Spinal Epidural Anesthesia for Cesarean Delivery and the Well-being of Newborns".CHINESE MEDICAL JOURNAL 128..14(2015):1922-1931
