机构：[1]Greater Los Angeles Healthcare System, Veteran’s Administration, Geriatric Research Education and Clinical Center, Los Angeles, USA[2]Department of Neurology, University of California, Los Angeles, USA[3]Department of Medicine, University of California, Los Angeles, USA[4]Department of Neurobiology and Neurology, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 10053, China神经内科老年医学科首都医科大学宣武医院
Curcumin, a polyphenolic antioxidant derived from the turmeric root has undergone extensive preclinical development, showing remarkable efficacy in wound repair, cancer and inflammatory disorders. This review addresses the rationale for its use in neurodegenerative disease, particularly Alzheimer's disease. Curcumin is a pleiotropic molecule, which not only directly binds to and limits aggregation of the beta-sheet conformations of amyloid characteristic of many neurodegenerative diseases but also restores homeostasis of the inflammatory system, boosts the heat shock system to enhance clearance of toxic aggregates, scavenges free radicals, chelates iron and induces anti-oxidant response elements. Although curcumin corrects dysregulation of multiple pathways, it may exert many effects via a few molecular targets. Pharmaceutical development of natural compounds like curcumin and synthetic derivatives have strong scientific rationale, but will require overcoming various hurdles including; high cost of trials, concern about profitability and misconceptions about drug specificity, stability, and bioavailability.
第一作者机构：[1]Greater Los Angeles Healthcare System, Veteran’s Administration, Geriatric Research Education and Clinical Center, Los Angeles, USA[2]Department of Neurology, University of California, Los Angeles, USA
通讯作者：
通讯机构：[1]Greater Los Angeles Healthcare System, Veteran’s Administration, Geriatric Research Education and Clinical Center, Los Angeles, USA[2]Department of Neurology, University of California, Los Angeles, USA[3]Department of Medicine, University of California, Los Angeles, USA
推荐引用方式(GB/T 7714)：
Shuxin Hu,Panchanan Maiti,Qiulan Ma,et al.Clinical development of curcumin in neurodegenerative disease[J].EXPERT REVIEW OF NEUROTHERAPEUTICS.2015,15(6):629-637.doi:10.1586/14737175.2015.1044981.
APA：
Shuxin Hu,Panchanan Maiti,Qiulan Ma,Xiaohong Zuo,Mychica R Jones...&Sally A Frautschy.(2015).Clinical development of curcumin in neurodegenerative disease.EXPERT REVIEW OF NEUROTHERAPEUTICS,15,(6)
MLA：
Shuxin Hu,et al."Clinical development of curcumin in neurodegenerative disease".EXPERT REVIEW OF NEUROTHERAPEUTICS 15..6(2015):629-637
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