机构：[1]Department of Neurology, Neurobiology and Geriatrics, National GCP Clinical Trial Center on Neurodegenerative Disease, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, #45 Changchun Street, Beijing 100053, China神经内科老年医学科首都医科大学宣武医院[2]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China神经内科首都医科大学宣武医院[3]Key Laboratory of Neurodegenerative Disease, Ministry of Education and Key Laboratory for Parkinson’s Disease, Beijing, Beijing 100053, China[4]Department of Neurology, Xiangya Hospital of Central South University, Changsha, China[5]Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
Non-motor symptoms (NMS) are common among patients with Parkinson's disease (PD). However, reports on NMS in Chinese PD population are scarce. Little is known about NMS in patients with Asian specific leucine-rich repeat kinase 2 (LRRK2) variants in G2385R and R1628P. This study aimed to elucidate the clinical characteristics of NMS in Chinese PD patients and to ascertain if there were differences in NMS between PD patients with and without LRRK2 variants. A multicenter, observational study was conducted with 1,225 sporadic PD (sPD) patients recruited from a PD cohort of the Chinese National Consortium on neurodegenerative diseases, 163 participants had the LRRK2 variants. The Non-motor Symptom Questionnaire (NMSQ) was used to screen for the presence of NMS. This study found the majority of sPD patients (97.6 %) had at least one NMS. A mean of 8.72 NMS (SD = 5.43) was reported per patient. Forgetfulness, constipation and daytime sleepiness were found to be the most frequent NMS. Moreover, the number of NMS was positively correlated with the age, disease duration, Hoehn & Yahr stage and the motor scores of the unified Parkinson's disease rating scale. Although no discrepancy was found in the number of NMS between sPD patients with and without LRRK2 variants, nocturia was less common in LRRK2 variants carriers than in non-carriers (P = 0.045). NMS appear to be prevalent in Chinese sPD population. There are no differences in the NMS phenotype between LRRK2 and no LRRK2 patients.
基金：
the National Basic Research Development Program of China (2011CB504101),
the Beijing high standard health human resource cultural program in health system (2009e1e12).
第一作者机构：[1]Department of Neurology, Neurobiology and Geriatrics, National GCP Clinical Trial Center on Neurodegenerative Disease, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, #45 Changchun Street, Beijing 100053, China[2]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China
通讯作者：
通讯机构：[1]Department of Neurology, Neurobiology and Geriatrics, National GCP Clinical Trial Center on Neurodegenerative Disease, Beijing Institute of Geriatrics, Xuanwu Hospital of Capital Medical University, #45 Changchun Street, Beijing 100053, China[2]Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing 100053, China[3]Key Laboratory of Neurodegenerative Disease, Ministry of Education and Key Laboratory for Parkinson’s Disease, Beijing, Beijing 100053, China
推荐引用方式(GB/T 7714)：
Da-Wei Li,Zhuqin Gu,Chaodong Wang,et al.Non-motor symptoms in Chinese Parkinson's disease patients with and without LRRK2 G2385R and R1628P variants[J].JOURNAL OF NEURAL TRANSMISSION.2015,122(5):661-667.doi:10.1007/s00702-014-1281-4.
APA：
Da-Wei Li,Zhuqin Gu,Chaodong Wang,Jinghong Ma,Bei-Sha Tang...&Piu Chan.(2015).Non-motor symptoms in Chinese Parkinson's disease patients with and without LRRK2 G2385R and R1628P variants.JOURNAL OF NEURAL TRANSMISSION,122,(5)
MLA：
Da-Wei Li,et al."Non-motor symptoms in Chinese Parkinson's disease patients with and without LRRK2 G2385R and R1628P variants".JOURNAL OF NEURAL TRANSMISSION 122..5(2015):661-667
