机构：[1]Department of Neurology, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou 215004, China[2]Institute of Neuroscience, Soochow University, Suzhou 215123,China[3]Department of Neurology, Hospital of Changshu Traditional Chinese Medicine, East Huanghe Road, Changshu 215000,China
Non-motor symptoms, including pain, depression, sleep disorder, and olfactory dysfunction, occur frequently in patients with Parkinson's disease (PD), even before the onset of motor symptoms. Although studies have examined the correlation between pain and depression or sleep disorder in PD, few studies have investigated the correlation between pain and a range of other non-motor symptoms of PD. PD patients (n = 142) with or without pain were included in the study. PD severity was evaluated with the Unified Parkinson's Disease Rating Scale (UPDRS) and the Hoehn and Yahr (H/Y) staging scale. Pain severity was analyzed with the Visual Analog Scale. The Hamilton Rating Scale for Depression (HRSD; 24 items), Montreal Cognitive Assessment Beijing Version (MoCA), and non-motor questionnaire (NMSQT) measured symptoms of depression, cognitive function, and non-motor symptoms. The incidence of pain was 47.9 % in patients with PD, most of whom had moderate pain levels. Patients with pain showed higher HRSD, UPDRS, H/Y, and NMSQT scores and lower MoCA scores compared to those of patients without pain. HRSD and NMSQT scores were closely related with pain (P < 0.001). Non-motor symptoms were more prominent in patients with pain compared to that of controls and PD patients without pain.
基金：
This work was supported by grants from A
Project Funded by the Priority Academic Program Development of
Jiangsu Higher Education Institutions; Jiangsu Key Laboratory of
Translational Research and Therapy for Neuro-Psycho-Diseases
(BM2013003); Jiangsu Provincial Special Program of Medical Science
(BL2014042); Suzhou Science and Technology Development
Program (SZS201205); Suzhou Clinical Key Disease Diagnosis and
Treatment Technology Foundation (LCZX201304).
第一作者机构：[1]Department of Neurology, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou 215004, China[2]Institute of Neuroscience, Soochow University, Suzhou 215123,China
共同第一作者：
通讯作者：
通讯机构：[1]Department of Neurology, Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, The Second Affiliated Hospital of Soochow University, Soochow University, Suzhou 215004, China
推荐引用方式(GB/T 7714)：
Cheng-Jie Mao,Ju-Ping Chen,Xiao-Yi Zhang,et al.Parkinson's disease patients with pain suffer from more severe non-motor symptoms[J].NEUROLOGICAL SCIENCES.2015,36(2):263-8.doi:10.1007/s10072-014-1942-y.
APA：
Cheng-Jie Mao,Ju-Ping Chen,Xiao-Yi Zhang,Yi Chen,Si-Jiao Li...&Chun-Feng Liu.(2015).Parkinson's disease patients with pain suffer from more severe non-motor symptoms.NEUROLOGICAL SCIENCES,36,(2)
MLA：
Cheng-Jie Mao,et al."Parkinson's disease patients with pain suffer from more severe non-motor symptoms".NEUROLOGICAL SCIENCES 36..2(2015):263-8
