机构：[1]Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China,首都医科大学宣武医院低氧医学研究室[2]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China,[3]Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China,[4]Department of Neurosurgery, Wayne State University School of Medicine, Detroit, MI, USA,[5]China-America Institute of Neuroscience, Department of Neurology, Luhe Hospital, Capital Medical University, Beijing, China,神经内科中美神经科学研究所首都医科大学宣武医院[6]The First Affiliated Hospital, Harbin Medical University, Harbin, China,[7]Department of Radiology, The Fifth Affiliated Hospital of Zunyi Medical University, Zhuhai,, China,[8]Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China神经外科首都医科大学宣武医院
Objectives: In a rat common carotid artery (CCA) stenosis model, the author determined the function of blood-brain barrier (BBB) at different time points and established an optimal time for CCA recanalization in rats with CCA stenosis combined with cerebral infarction. Methods: Common carotid artery severe stenosis combined with cerebral infarction was divided into two groups: CCA stenosis group (n = 48) and CCA stenosis recanalization group (n = 48). Common carotid artery stenosis recanalization was opened at time points of 1, 2, 3, 5, 7 and 14 days. Twenty-four hours after recanalization, neurological behaviour, motor function, brain water content and immunohistochemistry of laminin and fibronectin were used to assess brain injury. The peak systolic velocity (PSV) determined by colour Doppler flow imaging (CDFI) was used to assess blood flow of the CCA. Results: In contrast to CCA stenosis without recanalization, in which severe neurological deficits and foot fault were observed at 1, 2 and 3 days, significantly less neurological deficits at 14 days and less foot fault placing at 5, 7 and 14 days were observed after recanalization (P < 0.05). Although the brain water content was enhanced in the recanalization group at the stage of 1-3 days (P < 0.05), a decrease in recanalization group at all time points (1-14 days) was found. Being consistent with reduced brain oedema, the expression of laminin and fibronectin gradually increased in both groups. However, at the early phase of 7-14 days (vs acute phase), the levels of basal laminar proteins were significantly (P < 0.05) enhanced by vascular recanalization in both the ischaemic core and penumbra. Peak systolic velocity of CCA after recanalization reached the control level without stenosis. Conclusions: Our study suggests that the optimal time to open the CCA stenosis complicating cerebral infarction is at or after 7 days of CCA stenosis.
基金：
the National Science Fund for Distinguished Young Scholars of China (81325007).
第一作者机构：[1]Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University, Beijing, China,[2]Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China,[3]Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China,
通讯作者：
通讯机构：[*1]Xuanwu Hospital, Capital Medical University, Beijing 100053, China.
推荐引用方式(GB/T 7714)：
Qingtao Kong,Adam Hafeez,Wang Yu,et al.Acute recanalization of carotid stenosis is not proper: an experimental ischaemic stroke study[J].NEUROLOGICAL RESEARCH.2015,37(5):397-402.doi:10.1179/1743132815Y.0000000022.
APA：
Qingtao Kong,Adam Hafeez,Wang Yu,Changhong Ren,Xiaokun Geng...&Xunming Ji.(2015).Acute recanalization of carotid stenosis is not proper: an experimental ischaemic stroke study.NEUROLOGICAL RESEARCH,37,(5)
MLA：
Qingtao Kong,et al."Acute recanalization of carotid stenosis is not proper: an experimental ischaemic stroke study".NEUROLOGICAL RESEARCH 37..5(2015):397-402
