机构：[1]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing, China,首都医科大学宣武医院[2]Department of Physiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China,[3]Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China,[4]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China神经外科首都医科大学宣武医院
Objective: This study aimed to evaluate the efficacy of antireflux treatment on gastroesophageal reflux (GER)-related cough syncope. Methods: The method used was a retrospective review of the outcomes of antireflux treatment with proton pump inhibitor (PPI), Stretta radiofrequency (SRF), or laparoscopic fundoplication (LF) of 8 patients with chronic cough and cough syncope that was clinically evaluated to be GER related over a period of 2 to 5 years. Results: In the 8 selected cases, the typical GER symptoms disappeared in 7 cases and were significantly eased in I case. The chronic cough diminished to mild and occasional occurrence in 6 cases and was completely relieved in 2 cases. Meanwhile, the cough syncope disappeared in all cases. Seven of the patients resumed physical and social functions after the antireflux treatments, except for I person, who had a stroke due to other causes. Conclusion: For chronic cough and cough syncope of unknown cause, the GER assessment could be valuable. In treating well-selected GER-related chronic cough and cough syncope, PPI, SRF, and LF can be considered. Moreover, satisfactory restoration of physical and social functions could be achieved after effective antireflux therapy.
基金：
the National Science and Technology Major Project (2012ZX09102201-106 and 2009ZX09103-366);
National Natural Science Foundation of China (81173575, 30973893 and 81274173);
China Postdoctoral Science Foundation funded project (106455);
Beijing Natural Science Foundation (7102077 and 7211017);
Beijing Municipal Commission of Education & Capital Medical University Base-Technological Innovation Platform Fund (111219);
a grant of Beijing Health System Experts of High-level (2011-3-097);
Beijing Municipal Commission of Education (KM201010025004);
Beijing Postdoctoral Science Foundation funded project (106455).
第一作者机构：[1]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing, China,
通讯作者：
通讯机构：[1]Department of Pharmacology, Xuanwu Hospital of Capital Medical University, Beijing, China,[3]Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing, China,[4]Department of Neurosurgery, Xuanwu Hospital of Capital Medical University, Beijing, China
推荐引用方式(GB/T 7714)：
Fang-Ling Sun,Wen Wang,Hua Cheng,et al.Gastroesophageal Reflux in Chronic Cough and Cough Syncope and the Effect of Antireflux Treatment: Case Report and Literature Review[J].ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY.2014,123(10):719-725.doi:10.1177/0003489414534011.
APA：
Fang-Ling Sun,Wen Wang,Hua Cheng,Ying Wang,Lei Li...&Xun-Ming Ji.(2014).Gastroesophageal Reflux in Chronic Cough and Cough Syncope and the Effect of Antireflux Treatment: Case Report and Literature Review.ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY,123,(10)
MLA：
Fang-Ling Sun,et al."Gastroesophageal Reflux in Chronic Cough and Cough Syncope and the Effect of Antireflux Treatment: Case Report and Literature Review".ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY 123..10(2014):719-725
