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Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats

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收录情况： ◇ SCIE

作者：
Linlin Yin [a] * ; Yongyan Chen[b] ; Zhao Qu[c] ; Li Zhang [a] ; QiWang [c] ; Qi Zhang [b] ; Lin Li [a] ;
机构： [a]Department of Pharmacology, XuanWu Hospital of Capital Medical University, Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, 45 Changchun Street, Beijing 100053, PR China [b]School of Pharmaceutical Sciences, Zhengzhou University, 100 Science Avenue, Zhengzhou, Henan Province 450001, PR China [c]Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, 12 Jichang Road, Guangzhou, Guangdong Province 510405, PR China
出处：
DOI： 10.1016/j.jneuroim.2014.06.022
ISSN：

关键词： Experimental autoimmune encephalomyelitis Camel iridoid glycoside Multiple sclerosis JAK/STAT signaling Neuroinflammation

摘要：
In the present study, we investigated the therapeutic benefit of camel iridoid glycoside (CIG), the main component extracted from Cornus officinalis, in experimental autoimmune encephalomyelitis (EAE) rats. CIG was intragastrically administered daily after EAE initiation for 20 days and reduced disease severity, incidence, disease onset and ongoing paralysis. Histopathological staining showed that CIG could reduce T cell entry to the central nervous system and microglia activation, increased brain-derived neurotrophic factor (BDNF) expression and mature oligodendrocytes, and decreased oligodendrocyte progenitor cells (OPCs). Also, CIG treatment inhibited brain JAK/STAT1/3 and reduced proinflammatory cytokines. CIG might be a novel potential therapeutic agent for multiple sclerosis (MS). (C) 2014 Elsevier B.V. All rights reserved.

基金：
the National Natural Science Foundation of China (No. 81001656, 81341088, 81273817) Beijing Nova Star Program in Science and Technology (No. Z12111000250000) Capital Medical Development Special Program (No. 2011-1001-06) Beijing Organization Department of Municipal Party Committee Project for Highly Talented Man (2012D005018000010)
语种：
外文
被引次数：
WOS：
PubmedID：
中科院(CAS)分区：
出版当年[2013]版：
大类 | 3 区 医学
小类 | 3 区 免疫学 3 区 神经科学
最新[2023]版：
大类 | 4 区 医学
小类 | 4 区 免疫学 4 区 神经科学
JCR分区：
出版当年[2012]版：
Q2 IMMUNOLOGY Q2 NEUROSCIENCES
最新[2023]版：
Q2 NEUROSCIENCES Q3 IMMUNOLOGY

影响因子： 最新[2023版] 最新五年平均 出版当年[2012版] 出版当年五年平均 出版前一年[2011版] 出版后一年[2013版]

第一作者：
第一作者机构： [a]Department of Pharmacology, XuanWu Hospital of Capital Medical University, Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, 45 Changchun Street, Beijing 100053, PR China
通讯作者：
通讯机构： [a]Department of Pharmacology, XuanWu Hospital of Capital Medical University, Beijing Geriatric Medical Research Center, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, 45 Changchun Street, Beijing 100053, PR China
推荐引用方式(GB/T 7714)：
Linlin Yin,Yongyan Chen,Zhao Qu,et al.Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats[J].JOURNAL OF NEUROIMMUNOLOGY.2014,274(1-2):28-37.doi:10.1016/j.jneuroim.2014.06.022.
APA：
Linlin Yin,Yongyan Chen,Zhao Qu,Li Zhang,QiWang...&Lin Li.(2014).Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats.JOURNAL OF NEUROIMMUNOLOGY,274,(1-2)
MLA：
Linlin Yin,et al."Involvement of JAK/STAT signaling in the effect of cornel iridoid glycoside on experimental autoimmune encephalomyelitis amelioration in rats".JOURNAL OF NEUROIMMUNOLOGY 274..1-2(2014):28-37

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