机构：[1]Istituto Auxologico Italiano,[2]Universita` di Milano, Milan, Italy,[3]FuWai Hospital and Cardiovascular Institute,[4]Beijing Hypertension League Institute, Beijing, China,[5]Universita` Milano-Bicocca,[6]IRCCS Multimedica, Sesto San Giovanni, Milan, Italy,[7]Oslo University Hospital, Oslo, Norway,[8]University of Valencia, Madrid, Spain,[9]Medical University of Gdansk, Gdansk, Poland,[10]University of Glasgow, Glasgow,UK,[11]Lund University, Scania University Hospital, Malmo, Sweden,[12]Tallinn University of Technology, Tallinn, Estonia,[13]European Hospital Georges Pompidou, Paris, France,[14]Universita` di Brescia, Spedali Civili, Brescia, Italy,[15]Beijing Anzhen Hospital, Beijing,[16]Shanghai Hypertension Institute, Shanghai, China,[17]Complutense University,[18]Hospital 12 de Octubre,[19]Hospital Cl?′nico San Carlos, Madrid, Spain,[20]Centro Hospitalar de Entre o Douro e Vouga, E.P.E., Portugal,[21]Nephrology and Hypertension, University Hospital, Erlangen, Germany,[22]University Hospital of Lausanne, Lausanne,Switzerland,[23]Medical University of Lodz, Lodz, Poland,[24]Charles University Medical School I and Thomayer Hospital, Prague, Czech Republic,[25]St. Imre University Teaching Hospital, Budapest, Hungary,[26]Almazov Federal Heart, Blood and Endocrinology Center, St. Petersburg, Russia,[27]RSPC Cardiology, Minsk, Belarus,[28]NSC ‘Institute of Cardiology named after N.D. Strazhesko’ of NAMS, Kiev, Ukraine,[29]Emergency Hospital of Bucharest, Bucharest, Romania,[30]University Hospital Saint Anna, Sofia,Bulgaria,[31]Dr Peter Drzai Hospital, Ljubljana, Slovenia,[32]University Hospital Center Zagreb, Zagreb, Croatia,[33]Clinic for Internal Medicine InterMedic, Nis, Serbia,[34]Cardiology Department, Asklepeion General Hospital, Athens, Greece,[35]Nicosia General Hospital, Nicosia, Cyprus,[36]Istanbul University Cerrahpas?a School of Medicine, Istanbul, Turkey,[37]Hasharon Hospital – Rabin Medical Center, Petach-Tikva,Israel,[38]Beijing Xuanwu Hospital,首都医科大学宣武医院[39]Second Affiliate Hospital, Beijing University,[40]Military General Hospital, Beijing, China,[41]Hospital Clinic, University of Barcelona,Barcelona, Spain,[42]University of Cambridge, Cambridge[43]Oxford University Hospital NHS Trust, Oxford, UK
Background and objectives: It is well established by a large number of randomized controlled trials that lowering blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) by drugs are powerful means to reduce stroke incidence, but the optimal BP and LDL-C levels to be achieved are largely uncertain. Concerning BP targets, two hypotheses are being confronted: first, the lower the BP, the better the treatment outcome, and second, the hypothesis that too low BP values are accompanied by a lower benefit and even higher risk. It is also unknown whether BP lowering and LDL-C lowering have additive beneficial effects for the primary and secondary prevention of stroke, and whether these treatments can prevent cognitive decline after stroke. Results: A review of existing data from randomized controlled trials confirms that solid evidence on optimal BP and LDL-C targets is missing, possible interactions between BP and LDL-C lowering treatments have never been directly investigated, and evidence in favour of a beneficial effect of BP or LDL-C lowering on cognitive decline is, at best, very weak. Conclusion: A new, large randomized controlled trial is needed to determine the optimal level of BP and LDL-C for the prevention of recurrent stroke and cognitive decline.
第一作者机构：[1]Istituto Auxologico Italiano,[2]Universita` di Milano, Milan, Italy,[*1]Istituto Auxologico Italiano, Via L. Ariosto 13,20145 Milan, Italy
通讯作者：
通讯机构：[*1]Istituto Auxologico Italiano, Via L. Ariosto 13,20145 Milan, Italy
推荐引用方式(GB/T 7714)：
Alberto Zanchetti,Lisheng Liu,Giuseppe Mancia,et al.Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence[J].JOURNAL OF HYPERTENSION.2014,32(9):1741-1750.doi:10.1097/HJH.0000000000000253.
APA：
Alberto Zanchetti,Lisheng Liu,Giuseppe Mancia,Gianfranco Parati,Guido Grassi...&Gary Ford.(2014).Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence.JOURNAL OF HYPERTENSION,32,(9)
MLA：
Alberto Zanchetti,et al."Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence".JOURNAL OF HYPERTENSION 32..9(2014):1741-1750
